[Pyr1] -Apelin 13

Modify Date: 2024-01-02 18:33:46

[Pyr1] -Apelin 13 Structure
[Pyr1] -Apelin 13 structure
Common Name [Pyr1] -Apelin 13
CAS Number 217082-60-5 Molecular Weight 1532.81
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C70H109N21O16S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of [Pyr1] -Apelin 13


[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

 Names

Name [Pyr1]-Apelin-13
Synonym More Synonyms

 [Pyr1] -Apelin 13 Biological Activity

Description [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.
Related Catalog
In Vitro [Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1].
In Vivo [Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI[2].
References

[1]. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98.

[2]. Hajimashhadi Z, et al. Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats. Neuropeptides. 2017 Feb;61:15-22.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C70H109N21O16S
Molecular Weight 1532.81
PSA 613.26000
LogP -3.42
Index of Refraction 1.696
Storage condition -15°C

 Synonyms

PGLU-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
pQRPRLSHKGPMPF
Deltorphin I
PYR-RPRLSHKGPMPF-OH
GLP-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
5-Oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine
L-Phenylalanine, 5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-
PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
pyroglutamyl apelin-13