2070009-29-7

2070009-29-7结构式

中文名	纳曲酮D4
英文名	naltrexone-d4
中文别名	纳曲酮单体-D4 纳曲酮-D4(纳曲酮杂质4) 氘4-纳曲酮
英文别名	NALTREXONE-D4 (1S,5R,13R,17S)-4-{[(2,2,3,H)cyclopropyl]methyl}-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.0,1.0,1]octadeca-7,9,11-trien-14-one Naltrexone D4Q: What is Naltrexone D4 Q: What is the CAS Number of Naltrexone D4 Q: What is the storage condition of Naltrexone D4 Q: What e the applications of Naltrexone D4 D4-Naltrexon

描述	Naltrexone-d4 是 Naltrexone 氘代物。Naltrexone是μ, κ, δ和σ-阿片受体拮抗剂。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体信号通路 >> 神经信号通路 >> 阿片受体研究领域 >> 神经疾病
体外研究	氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Lobmaier PP, et al. Naltrexone depot formulations for opioid and alcohol dependence: a systematic review. CNS Neurosci Ther. 2011 Dec;17(6):629-36. [3]. Mannelli P, Peindl KS, Wu LT. Pharmacological enhancement of naltrexone treatment for opioid dependence: a review. Subst Abuse Rehabil. 2011 Jun;2011(2):113-123. [4]. Swift R, Oslin DW, Alexander M, Forman R. Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review. J Stud Alcohol Drugs. 2011 Nov;72(6):1012-8. [5]. Makowski CT, Gwinn KM, Hurren KM. Naltrexone/bupropion: an investigational combination for weight loss and maintenance. Obes Facts. 2011;4(6):489-94. [6]. Hulse GK. Improving Clinical Outcomes for Naltrexone as a Management of Problem Alcohol Use. Br J Clin Pharmacol. 2012 Sep 5. doi: 10.1111/j.1365-2125.2012.04452.x. [7]. Naltrexone

分子式	C₂₀H₁₉D₄NO₄
分子量	345.43