503614-92-4

• 常用中文名：1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-3-羧酸
• 常用英文名：1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid
• CAS号：503614-92-4
• 分子式：C₂₅H₂₄N₄O₅
• 分子量：460.482
• 发布时间：2018-12-10 09:07:35
• 更新时间：2026-07-08 21:23:36

名称

• 中文名: 1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-3-羧酸
• 英文名: 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxylic acid
• 中文别名: APIXABAN ACID 杂质; 阿哌沙班杂质BMS-591; 1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-3-羧酸; 进口资料代码-BMS-591455-01; 阿皮沙班羧酸; 阿哌沙班杂质41(BMS-591455-01); 阿哌沙班杂质E; 阿哌沙班杂质BMS-591455; A阿哌沙班杂质BMS-591; APIXABAN中间体; 阿哌沙班杂质SS; 阿哌沙班杂质41; 1-(4-甲氧基苯基)-7-氧代-6-(4-(2-氧代哌啶-1-基)苯基-4,5,6,7-四氢-1H-吡唑[3,4-C]吡啶-3-甲酸; 阿哌沙班06; 阿哌沙班杂质; 1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1; 阿哌沙班杂质E对照品; 阿哌沙班杂质BMS-591455- 01黄金现货; 阿哌沙班杂质06; 阿哌沙班杂质1(环丙羧酸)(BMS-591455-01)
• 英文别名: Apixaban Impurity A / Apixaban Cboxylic Acid Impurity; Apixaban-5; Apixaban Impurity BMS-591455-01; 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-cboxylic acid; 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid; 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4; 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-cboxylicaci; 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-cboxylic Acid- 13C, D3; Apixaban Impurity SS; 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]; Apixaban acid impuity 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1- piperidinyl) phenyl]-1H-pyrazolo[3,4-c]pyridine-3-cboxylic acid; methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo 3,4-clpyridine-3-cboxylic acid; Apixaban Cboxylic Acid; Apixaban impurity 2/1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-cboxylic acid; 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-cboxylic acid; Impurity of apixaban379; Apixaban ImpurityMS-591455-01; Apixaban Acid; 503-4 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-cboxylic acid; APIXABAN ACID IMP; Apixaban Impurity 1(Cboxylic Acid )(BMS-591455-01); Apixaban Acid Impurity; Apixaban impurity 01; Impurity of apixaban1719; Apixaban Cboxylic Acid Imp; TECO-010; 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-cboxylic acid; 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihy; Apixaban Cboxylic Acid Impurity; Apixaban Impurity A; 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-cboxylic acid; Apixaban Impurity 41 (BMS-591455-01); Apixaban Impurity A (BMS-591455-01); Apixaban iMpurity(BMS-591455; Apixaban Impurity 1（Cboxylic Acid ）; 1H-Pyrazolo[3,4-c]pyridine-3-cboxylic acid, 4,5,6,7-tetrahydro-1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]; BMS-589154-01

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 807.2±65.0 °C at 760 mmHg
• 分子式: C₂₅H₂₄N₄O₅
• 分子量: 460.482
• 闪点: 442.0±34.3 °C
• 精确质量: 460.174683
• PSA: 104.97000
• LogP: 1.63
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.695
• 储存条件: 2-8°C，干燥密封

合成路线

675-20-7 473927-64-9 ~30% 503614-91-3 503614-92-4

文献：ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef Patent: WO2014/75648 A1, 2014 ; Location in patent: Page/Page column 13 ;

385425-15-0 148-24-3 503614-56-0 ~% 503614-92-4

文献：Zhou, Jiacheng; Oh, Lynette M.; Ma, Philip; Li, Hui-Yin; Confalone, Pasquale Patent: US2003/181466 A1, 2003 ;

27143-07-3 ~% 503614-92-4

文献：ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef Patent: WO2014/75648 A1, 2014 ;

473927-69-4 ~% 503614-92-4

文献：ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef Patent: WO2014/75648 A1, 2014 ;

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