472967-95-6

• 常用中文名：(3S,5S)-阿托伐他汀乙酰丙酮叔丁基酯
• 常用英文名：tert-butyl 2-[(4S,6S)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
• CAS号：472967-95-6
• 分子式：C₄₀H₄₇FN₂O₅
• 分子量：654.81000
• 发布时间：2017-03-17 19:43:15
• 更新时间：2026-08-16 11:21:17

名称

• 中文名: (3S,5S)-阿托伐他汀乙酰丙酮叔丁基酯
• 英文名: tert-butyl 2-[(4S,6S)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
• 中文别名: (3S,5S)-阿托伐他汀丙酮叔丁酯; 阿托伐他汀钙杂质33对照品; 阿托伐他汀钙杂质33; 阿托伐他汀杂质33; 2-甲基-2-丙基(6-{2-[2-(4-氟苯基)-5-异丙基-3-苯基-4-(苯基氨基甲酰)-1H-吡咯-1-基]乙基}-2,2-二甲基-1,3-二恶烷-4-基)乙酸酯; 阿托伐他汀乙酰丙酮叔丁基酯(3S,5S)-异构体; 阿托伐他汀丙酮叔丁酯
• 英文别名: 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S,6S); Atorvastatin Acetonide t-Butyl Ester (4S,6S)-Isomer; (4S,6S)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester; Atorvastatin Acetonide t-Butyl Ester (3S,5S)-Isomer; ATV-1 acetonide; Atorvastatin calcium-24; 4S,6S)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl; Atorvastatin impurity 23/(3S,5S)-Atorvastatin Acetonide tert-Butyl Ester/(4S,6S)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester; (4S,6S)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenyl amino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid t-butyl ester; Atorvastatin calcium impurity 33; (4S,6S)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Este; (3S,5S)-Atorvastatin Acetonide tert-Butyl Ester; tert-butyl 2-[(4S,6S)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcbamoyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate; Atorvastatin acetonide; tert-butyl 2-((4S,6S)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3- phenyl-4-(phenylcbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2- dimethyl-1,3-dioxan-4-yl)acetate

物化性质

• 密度: 1.15g/cm3
• 沸点: 678.035ºC at 760 mmHg
• 分子式: C₄₀H₄₇FN₂O₅
• 分子量: 654.81000
• 闪点: 363.863ºC
• 精确质量: 654.34700
• PSA: 78.79000
• LogP: 9.44200
• 外观性状: 淡黄色固体
• 折射率: 1.569

合成路线

947586-93-8 125971-96-2 ~% 472967-95-6

文献：Collection of Czechoslovak Chemical Communications, , vol. 73, # 2 p. 229 - 246

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