2378-95-2

• 常用中文名：对甲胺基苯甲酰谷氨酸二乙酯
• 常用英文名：Diethyl N-[4-(methylamino)benzoyl]-L-glutamate
• CAS号：2378-95-2
• 分子式：C₁₇H₂₄N₂O₅
• 分子量：336.383
• 相关类别： 生物化工 氨基酸及其衍生物 谷氨酸类衍生物
• 发布时间：2018-02-09 08:00:00
• 更新时间：2026-07-03 09:06:36

名称

• 中文名: 对甲胺基苯甲酰谷氨酸二乙酯
• 英文名: diethyl (2S)-2-[[4-(methylamino)benzoyl]amino]pentanedioate
• 中文别名: 甲氨蝶呤INT1; 对甲氨基苯甲酰谷氨酸二乙脂; (S)-2-(4-(甲基氨基)苯甲酰氨基)戊二酸二乙酯; 二乙基(4-(甲氨基)苯甲酰基)-L-谷氨酸; 甲氨蝶呤杂质18; N-[4-(甲基氨基)苯甲酰基]-L-谷氨酸二乙酯; L-对甲氨基苯甲酰谷氨酸二乙酯; 对甲氨基苯甲酰谷氨酸二乙酯
• 英文别名: N-(4-MethylaMinobenzoyl)-L-lutaMic acid diethylester; iethyl(2S)-2-[[4-(methylamino)benzoyl]amino]pentanedioate; diethyl N-(p-methylaminobenzoyl)-L-glutamate; diethyl N-[4-(methylamino)benzoyl]-L-glutamate; (S)-Diethyl 2-(4-(methylamino)benzamido)pentanedioate; Diethyl N-(4-methylamino) benzoyl-L-glutamatel; Methotrexate Impurity 18; L-Glutamic acid, N-[4- (methylamino)benzoyl]-, diethyl ester; diethyl 4-(methylamino)benzoyl-L-glutamate; N-(4-N-Methylaminobenzoyl)-L-glutamic acid diethyl ester; 1,5-Diethyl N-[4-(methylamino)benzoyl]-L-glutamate; Diethyl N-(p-N-methylaminobenzoyl)glutamate; L-Glutamic acid, N-[4-(methylamino)benzoyl]-, diethyl ester; ethyl N-[p-(Methylamino)Benzoyl]-L-Glutamate; N-[4-(METHYLAMINO)BENZOYL]-L-GLUTAMATE; (S)-DIETHYL 2-(4-(METHYLAMINO)BENZAMIDO)PENTANEDIOATE; N-(p-Methylaminobenzoyl)glutamic acid diethyl ester; P-N-Methylaminobenzoyl Glutamic Acid Diethyl Ester; (2S)-2-[[4-(Methylamino)benzoyl]amino]glutic acid diethyl ester; diethyl (4-(methylamino)benzoyl)-L-glutamate; diethyl N-<4-(methylamino)benzoyl>AC1Q63IM; diethyl N-[4-(methylamino)benzoyl]-L-glutamate //BP; diethyl p-methylaminobenzoyl-L-glutamate; N-(4-Methylaminobenzoyl)-L-Glutamic Acid Diethyl ester; DIETHYL-N-(PA-METHYLAMINOBENZOYL)-L-GLUTAMATE; Diethyl p-methylaminobenzoyl glutamate; L-GLUTAMIC ACID,N-[4-(METHYLAMINO)BENZOYL]-, 1,5-DIETHYL ESTER; diethyl <4-(N-methylamino)benzoyl>-L-glutamate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 518.3±50.0 °C at 760 mmHg
• 熔点: 88-89 °C
• 分子式: C₁₇H₂₄N₂O₅
• 分子量: 336.383
• 闪点: 267.2±30.1 °C
• 精确质量: 336.168518
• PSA: 93.73000
• LogP: 2.48
• 外观性状: 固体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.536
• 储存条件: 室温，避光，干燥，密封

安全

• 危害码 (欧洲): Xn
• 海关编码: 2924299090

合成路线

115827-03-7 ~77% 2378-95-2

文献：Yang; Slusher; Broom; Ueda; Cheng Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2126 - 2132

13726-52-8 74-88-4 ~23% 2378-95-2

文献：Jones; Thornton; Flinn; Jackman; Newell; Calvert Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 847 - 852

13726-52-8 ~% 2378-95-2

文献：Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2126 - 2132

70280-70-5 ~% 2378-95-2

文献：Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2126 - 2132

38974-68-4 74-89-5 ~% 2378-95-2

文献：Journal of the American Chemical Society, , vol. 70, p. 1922,1925

13726-52-8 584-08-7 74-88-4 ~% 2378-95-2

文献：US5236927 A1, ;

4271-30-1 ~% 2378-95-2

文献：Journal of the American Chemical Society, , vol. 70, p. 1922,1925

上下游产品

上游产品  8
115827-03-7 13726-52-8 74-88-4 70280-70-5
38974-68-4 74-89-5 584-08-7 4271-30-1
下游产品  2
59-05-2 76822-62-3

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%