135525-71-2

• 常用中文名：L 696229
• 常用英文名：L 696229
• CAS号：135525-71-2
• 分子式：C₁₇H₁₈N₂O₂
• 分子量：282.33700
• 相关类别： 信号通路 抗感染 HIV
• 发布时间：2016-05-19 22:09:51
• 更新时间：2024-01-05 22:11:27
• L 696229是人类免疫缺陷病毒1型(HIV-1)逆转录酶活性的特异性抑制剂,具有抗病毒活性。

名称

• 英文名: 3-[2-(1,3-benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-1H-pyridin-2-one
• 英文别名: 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-pyridin-2(1H)-one; 2-pyridinol,3-[2-(2-benzoxazolyl)ethyl]-5-ethyl-6-methyl; 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-2-(1H)-pyridinone

物化性质

• 密度: 1.149g/cm3
• 沸点: 496.5ºC at 760mmHg
• 分子式: C₁₇H₁₈N₂O₂
• 分子量: 282.33700
• 闪点: 254.1ºC
• 精确质量: 282.13700
• PSA: 59.15000
• LogP: 3.58440
• 蒸汽压: 5.37E-10mmHg at 25°C
• 折射率: 1.58

生物活性

• 描述: L 696229是人类免疫缺陷病毒1型(HIV-1)逆转录酶活性的特异性抑制剂,具有抗病毒活性。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Goldman ME, et al. L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro. Antimicrob Agents Chemother. 1992;36(5):1019-1023.

合成路线

139548-67-7 ~93% 135525-71-2

文献：Saari; Hoffman; Wai; Fisher; Rooney; Smith; Thomas; Goldman; O'Brien; Nunberg; Quintero; Schleif; Emini; Stern; Anderson Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2922 - 2925

136562-05-5 ~% 135525-71-2

文献：Saari; Hoffman; Wai; Fisher; Rooney; Smith; Thomas; Goldman; O'Brien; Nunberg; Quintero; Schleif; Emini; Stern; Anderson Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2922 - 2925

139393-87-6 ~% 135525-71-2

文献：Saari; Hoffman; Wai; Fisher; Rooney; Smith; Thomas; Goldman; O'Brien; Nunberg; Quintero; Schleif; Emini; Stern; Anderson Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2922 - 2925

95-21-6 ~% 135525-71-2

文献：Hoffman; Smith; Rooney; Fisher; Wai; Thomas; Bamberger; Barnes; Williams; Jones; Olson; O'Brien; Goldman; Nunberg; Quintero; Schleif; Emini; Anderson Journal of Medicinal Chemistry, 1993 , vol. 36, # 8 p. 953 - 966

139393-89-8 ~% 135525-71-2

文献：Saari; Hoffman; Wai; Fisher; Rooney; Smith; Thomas; Goldman; O'Brien; Nunberg; Quintero; Schleif; Emini; Stern; Anderson Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2922 - 2925

107-87-9 ~% 135525-71-2

文献：Saari; Hoffman; Wai; Fisher; Rooney; Smith; Thomas; Goldman; O'Brien; Nunberg; Quintero; Schleif; Emini; Stern; Anderson Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2922 - 2925

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