100898-63-3

• 常用中文名：N-(1-((2R,4S,5R)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-羟基四氢呋喃-2-基)-2-氧代-1,2-二氢嘧啶-4-基)乙酰胺
• 常用英文名：5'-O-DMT-N4-Ac-dC
• CAS号：100898-63-3
• 分子式：C₃₂H₃₃N₃O₇
• 分子量：571.62000
• 相关类别： 生物化工 核苷类药物 脱氧核苷酸及其类似物
• 发布时间：2019-01-01 13:18:45
• 更新时间：2026-07-01 13:04:50
• 5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7),一种脱氧核苷,可用于合成十二烷基亚磷酰胺 (一种合成两亲 DNA 的原料)。

名称

• 中文名: N-乙酰基-5'-O-(4,4'-二甲氧基三苯甲基)-2'-脱氧胞苷
• 英文名: 5'-o-(4,4'-dimethoxytrityl)-n4-acetyl-2'-deoxycytidine
• 中文别名: 乙酰基-5'-O-(4,4'-二甲氧基三苯甲基)-2'-脱氧胞苷; N-(1-((2r,4s,5r)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-羟基四氢呋喃-2-基)-2-氧代-1,2-二氢嘧啶-4-基)乙酰胺; 5'-DMT-N4-乙酰基-2'-脱氧胞苷; N4-乙酰基-5'-O-(4,4'-二甲氧基三苯甲基)-2'-脱氧胞苷; DMT-N4-乙酰基-2'-脱氧胞苷; DMT保护性脱氧胞苷 (AC); N4-乙酰基-5'-O-DMT-2'-脱氧胞苷; N4-乙酰基-2'-脱氧-5'-O-DMT-胞苷
• 英文别名: DMT-N4-Ac-dC; 5''-O-(4,4''-Dimethoxytrityl)-N4-acetyl-2''-deoxycytidine (synthetic); 5'-ODMT N-Ac dC; N-(1-((2R,4S,5R); N4-Acetyl-5'-O-DMT -2' -deoxycytidine, Ac-DMT-dC; N-(1-((2R,4S,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyriMidin-4-yl)acetaMide; N-ACETYL-5'-DMT DEOXYCYTIDINE; 5'-O-DMT-N4-Acetyl-2'-deoxycytidine; 2-oxo-1,2-dihydropyrimidin-4-yl); N4-ACETYL-2'-DEOXY-5'-O-DMT-CYTIDINE; 5’-O-DMTr-2’-deoxycytidine (N-Ac); N4-Acetyl-2'-deoxy-5'-O-DMT-D-cytidine; 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ACETYL-2'-DEOXYCYTIDINE //BP; N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine; 5’-O-DMT-2’-Deoxy-N4-Acetyl-Cytidine; 5'-O-(4,4'-Dimethoxytrityl)-n4-acetyl-2'-deoxycytidine; N4-Acetyl-2'-Deoxy-5'-O-Dmt-D-Cytidine; DMT-Ac-dC; DMT-dC(Ac); N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide; 5'-O-DMT-2'-dC(ac); 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine; N4-Ac-DMT-dC; 4-hydroxytetrahydrofuran-2-yl); N-Acetyl-5'-O-[bis(4-methoxyphenyl)-phenylmethyl]-2'-deoxy-cytidine; DMT-NAC-DC; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy; 5'-DMT-N4-Ac-dC; 5'-O-DMT-2'-Deoxy-N4-Acetyl-Cytidine; 5'-DMT-Ac-dC; 5'-O-dimethoxytrityl-4-N-acetyl-2'-deoxycytidine; N4-ACETYL-2'-DEOXY-5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-CYTIDINE; N4-Acetyl-5''-O-(4,4''-dimethoxytrityl)-2''-deoxycytidine; N-ACETYL-5'-O-[BIS(4-METHOXYPHENYL)-PHENYLMETHYL]-2'-DEOXY-CYTIDINE; N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine; N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE; N4-Ac-5'-O-DMT-2'-dC; 5'-O-DMTr-2'-dC(Ac); 5’-DMT-2’-dC(Ac); N4-Acetyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-cytidine; Ac-DMT-dC; N-Acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxycytidine; N-ACETYL-5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-DEOXY-CYTIDINE; 5'-DMTr-N4-acetyl-2'-deoxycytidine

物化性质

• 分子式: C₃₂H₃₃N₃O₇
• 分子量: 571.62000
• 精确质量: 571.23200
• PSA: 121.14000
• LogP: 3.94900
• 储存条件: Store dry at 2-8°C

生物活性

• 描述: 5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7),一种脱氧核苷,可用于合成十二烷基亚磷酰胺 (一种合成两亲 DNA 的原料)。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 其他
• 参考文献:

  [1]. Dohno C, et, al. Amphiphilic DNA Duplex Stabilized by a Hydrophobic Zipper. European Journal of Organic Chemistry. September 2012. 27: 5317-5323.

合成路线

951-77-9 ~% 100898-63-3

文献：Nucleosides and Nucleotides, , vol. 16, # 7-9 p. 1589 - 1598

40615-36-9 32909-05-0 ~86% 100898-63-3

文献：Reddy; Hanna, Naeem B.; Farooqui, Firdous Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1589 - 1598