761438-38-4

• 常用中文名：2-[[5-氯-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]-N-甲基苯磺酰胺
• 常用英文名：ALK inhibitor 2
• CAS号：761438-38-4
• 分子式：C₂₃H₂₈ClN₇O₃S
• 分子量：518.03200
• 相关类别： 信号通路 蛋白酪氨酸激酶 ALK
• 发布时间：2017-09-17 20:42:08
• 更新时间：2026-07-17 19:26:43
• ALK抑制剂2是新型ALK选择性抑制剂。

名称

• 中文名: 2-[[5-氯-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]-N-甲基苯磺酰胺
• 英文名: 2-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-N-methylbenzenesulfonamide
• 中文别名: 2-((5-氯-2-((2-甲氧基-4-(4-甲基哌嗪-1-基)苯基)氨基)嘧啶-4-基)氨基)-N-甲基苯磺酰胺; 2-((5-氯-2-(((2-甲氧基-4-(4-甲基哌嗪-1-基)苯基)苯基)氨基)嘧啶-4-基)氨基)-N-甲基苯甲酰苯胺; ALK抑制剂(ALK INHIBITOR 2)
• 英文别名: BenzenesulfonaMide, 2-[[5-chloro-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]amino]-4-pyriMidinyl]amino]-N-Methyl; ALK tyrosine kinase rector,kinase,Anaplastic lymphoma kinase (ALK),Anaplastic lymphoma kinase,CD246,testis-specific,ALK inhibitor 2,serine/threonine,adhesion,Inhibitor,focal,PTK2 protein tyrosine kinase 2,PTK2,contraction,Cluster of differentiation 246,reversible,ALK inhibitor-2,ALK inhibitor2,inhibit,FAK,Focal adhesion kinase,TSSK2,male; CS-0796; 2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide; 2-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl; 2-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]-N-methylbenzene-1-sulfonamide; 2-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide

物化性质

• 分子式: C₂₃H₂₈ClN₇O₃S
• 分子量: 518.03200
• 精确质量: 517.16600
• PSA: 123.33000
• LogP: 4.25520
• 储存条件: 2-8℃

生物活性

• 描述: ALK抑制剂2是新型ALK选择性抑制剂。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> ALK
  研究领域 >> 癌症
• 参考文献:

  [1]. A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase (ALK).