60142-95-2

• 常用中文名：加巴喷丁盐酸盐
• 常用英文名：Gabapentin HCl
• CAS号：60142-95-2
• 分子式：C₉H₁₈ClNO₂
• 分子量：207.69800
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) GABA Receptor 激动剂
• 发布时间：2018-10-16 23:15:47
• 更新时间：2026-07-01 06:34:48
• Gabapentin (Neurontin)盐酸盐是GABA类似物，可用于缓解神经性疼痛。

名称

• 中文名: 加巴喷丁盐酸盐
• 英文名: 2-[1-(aminomethyl)cyclohexyl]acetic acid,hydrochloride
• 中文别名: 盐酸加巴喷丁
• 英文别名: 1-(Amino Methyl) Cyclohexane Acetic Acid Hydrochloride Hemihydrate Salt; Neurontin hydrochloride; Cyclohexaneacetic acid, 1-(aminomethyl)-, hydrochloride (1:1); Gabapentin HCl (Neurontin); Gabapentin HCl/(1-Aminomethyl Cyclohexan acetic Acid Hydrochloride); Neurontin; Inhibitor,Gabapentin hydrochloride,Gabapentin,Calcium Channel,Ca channels,inhibit,Ca2+ channels; 1-(aminomethyl)cyclohexaneacetic acid hydrochloride; UNII-N0PY5N5AFW; 1-AMINOMETHYL CYCLOHEXANACTIC ACID HYDROCHLORIDE; Gabapentin (hydrochloride); S1338_Selleck; Neurontin HCl; 2-(1-(aminomethyl)cyclohexyl)acetic acid hydrochloride; Gabarone,Neurontin,Gabapentin Hydrochloride; 2-[1-(aminomethyl)cyclohexyl]acetic acid hydrochloride; Gabarone; GABAPENTIN-D6 HYDROCHLORIDE //BP; GABAPENTIN-D6 HYDROCHLORIDE; 1-(Aminomethyl)cyclohexaneacetic acid hydrochloride

物化性质

• 沸点: 314.4ºC at 760mmHg
• 熔点: 148-151℃ (ethanol )
• 分子式: C₉H₁₈ClNO₂
• 分子量: 207.69800
• 闪点: 144ºC
• 精确质量: 207.10300
• PSA: 63.32000
• LogP: 2.87260
• 储存条件: -20°C

生物活性

• 描述: Gabapentin (Neurontin)盐酸盐是GABA类似物,可用于缓解神经性疼痛。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Receveur JM, et al. Synthesis and biological evaluation of conformationally restricted Gabapentin analogues. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2329-34.

  [2]. Parker DA, et al. Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices. Eur J Pharmacol. 2004 Jul 14;495(2-3):137-43.

  [3]. Stefani A, et al. Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology. 1998;37(1):83-91.

  [4]. Lee BS, et al. Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic pain. J Korean Med Sci. 2013 Feb;28(2):308-14.

  [5]. Harden RN, et al. A Phase 2a, Randomized, Crossover Trial of Gabapentin Enacarbil for the Treatment of Postherpetic Neuralgia inGabapentin Inadequate Responders. Pain Med. 2013 Sep 18.