1404-04-2

1404-04-2结构式

常用中文名：新霉素B
常用英文名：Neomycin
CAS号：1404-04-2
分子式：C₂₃H₅₂N₆O₂₅S₃
分子量：614.644
相关类别：原料药抗生素类药物氨基糖苷类药
发布时间：2018-08-30 22:03:20
更新时间：2024-01-02 13:37:42
Neomycin是一种氨基糖苷类抗生素。Neomycin可用于研究外部或内部细菌感染,主要以硫酸盐形式用于兽医学。

中文名	新霉素
英文名	neomycin sulfate
中文别名	新霉素B
英文别名	Actilin neomin Neosulf neomcin nivemycin Myacine EINECS 215-773-1 NEOMIX Endomixin Bykomycin Neobiosamine B Framygen Jernadex Antibiotique EF 185 (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-a-D-glucopyranoside myacyne Enterfram α-D-Glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2-[[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy- Bycomycin neolate Neomyacin Neobrettin Framycetin Biosol Tuttomycin a-D-glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2-[[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy- Fraquinol Neomycin (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside neomas

描述	Neomycin是一种氨基糖苷类抗生素。Neomycin可用于研究外部或内部细菌感染,主要以硫酸盐形式用于兽医学。
相关类别	研究领域 >> 感染
参考文献	[1]. Liu Y, et al. Pharmacokinetics of neomycin sulfate after intravenous and oral administrations in swine. J Vet Pharmacol Ther. 2021 Sep;44(5):850-853.

密度	1.6±0.1 g/cm3
沸点	927.1±65.0 °C at 760 mmHg
分子式	C₂₃H₅₂N₆O₂₅S₃
分子量	614.644
闪点	514.5±34.3 °C
精确质量	614.312256
PSA	602.05000
LogP	-3.65
外观性状	powder
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.675
储存条件	2-8°C
水溶解性	H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.
分子结构	1、摩尔折射率：无可用的 2、摩尔体积（cm³/mol）：无可用的 3、等张比容（90.2K）：无可用的 4、表面张力（dyne/cm）：无可用的 5、介电常数：无可用的 6、极化率（10^-24cm³）：无可用的 7、单一同位素质量：908.214421 Da 8、标称质量：908 Da 9、平均质量：908.8792 Da
计算化学	1.疏水参数计算参考值（XlogP）:-9 2.氢键供体数量:13 3.氢键受体数量:19 4.可旋转化学键数量:9 5.互变异构体数量:无 6.拓扑分子极性表面积353 7.重原子数量:42 8.表面电荷:0 9.复杂度:872 10.同位素原子数量:0 11.确定原子立构中心数量:19 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：白色或类白色粉末 2. 密度（g/mL,25℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：57-58 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,3mmHg）：未确定 7. 折射率(n20/D)：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（mmHg,20ºC）：未确定 12. 饱和蒸气压（kPa,25ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：极易溶于水，极微溶于乙醇，不溶于乙醚、丙酮、氯仿

毒理学数据:

1、急性毒性：女人经口TDLo：220mg/kg/2D；人TDLo：57mg/kg；大鼠经口LD50：2750mg/kg；大鼠经皮下LD50：633mg/kg；小鼠经口LD50：2880mg/kg；小鼠经腹腔LD50：116mg/kg；小鼠经皮下LD50：275mg/kg；小鼠经静脉LD50：27600μg/kg；

2、其他多剂量毒性：大鼠经皮下TDLo：500mg/kg/5D-I；

3、致突变性

大肠杆菌的DNA加和：20mg/L；

人淋巴细胞的细胞遗传学分析：80 mg/L/24H（Continuous）；

小鼠肠外的细胞遗传学分析：50 mg/kg；

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QP3850000

CHEMICAL NAME :: Neomycin

CAS REGISTRY NUMBER :: 1404-04-2

LAST UPDATED :: 199609

WISWESSER LINE NOTATION :: T6OTJ CZ DQ EQ F1Z BO- CT5OTJ B1Q DQ EO- CL6TJ AZ BQ EZ DO- BT6OTJ CZ DQ EQ F1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 220 mg/kg/2D

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - changes in cochlear structure or function Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 633 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg/5D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

REFERENCE :: CHRTBC Chromosomes Today. (George Allen & Unwin Ltd., 40 Museum St., London WC1A 1LU, UK) V.1- 1966- Volume(issue)/page/year: 4,277,1973 *** REVIEWS *** TOXICOLOGY REVIEW CPJOAC Canadian Pharmaceutical Journal. (Canadian Pharmaceutical Assoc., 101-1815 Alta Vista Dr., Ottawa, Ont., Canada) V.1- 1868- Volume(issue)/page/year: 108(3),88,1975 TOXICOLOGY REVIEW CLANA4 Clinical Anesthesia. (Philadelphia, PA 19103) V.1-11, 1963-76. Volume(issue)/page/year: 10(Pt 1),283,1973 TOXICOLOGY REVIEW MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973. Volume(issue)/page/year: 115,1661,1973 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3705 No. of Facilities: 567 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 19997 (estimated) No. of Female Employees: 16532 (estimated)

危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R42/43
安全声明 (欧洲)	S22;S45;S36/S37
WGK德国	3
RTECS号	QP4375000

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