| 中文名 | 氧杂酸酐 |
|---|---|
| 英文名 | 3a,4,7,7a-Tetrahydro-4,7-epoxyisobenzofuran-1,3-dione |
| 英文别名 |
4,10-Dioxatricyclo[5.2.1.0]dec-8-ene-3,5-dione
3,6-Endoxo-1,2,3,6-tetrahydrophthalic Anhydride 3,6-oxo-1,2,3,6-tetrahydrophthalic anhydride 4,7-Epoxyisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydro- 4,10-Dioxa-tricyclo[5.2.1.0]dec-8-ene-3,5-dione 4,10-dioxatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione 7-Oxabicyclo[2.2.1]-5-heptene-2,3-dicarboxylic Anhydride |
| 描述 | 4,10-二恶三环[5.2。1.02.6]癸-8-烯-3,5-二酮是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。 |
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| 相关类别 | |
| 参考文献 |
| 密度 | 1.5±0.1 g/cm3 |
|---|---|
| 沸点 | 372.0±42.0 °C at 760 mmHg |
| 分子式 | C8H6O4 |
| 分子量 | 166.13 |
| 闪点 | 172.2±27.9 °C |
| 精确质量 | 166.026611 |
| PSA | 52.60000 |
| LogP | -0.77 |
| 外观性状 | 固体 |
| 蒸汽压 | 0.0±0.8 mmHg at 25°C |
| 折射率 | 1.584 |
| 储存条件 | 2-8°C，惰性气体 |
Synonym:7-Oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic anhydrid Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated.Moisture sensitive. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. Ingestion: May cause digestive tract disturbances. The toxicological properties of this substance have not been fully investigated. Inhalation: Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Causes irritation of mucous membrane. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Antidote: None reported. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Do NOT use water directly on fire. In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 5426-09-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white - white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 118 deg C dec Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C8H8O3 Molecular Weight: 166.13 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. May decompose on exposure to moist air or water. Conditions to Avoid: Incompatible materials, dust generation, strong oxidants, exposure to moist air or water. Incompatibilities with Other Materials: Strong oxidizing agents - strong acids - strong bases. Hazardous Decomposition Products: Hydrogen chloride, phosgene, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 5426-09-5 unlisted. LD50/LC50: Not available. Carcinogenicity: 3,6-Endoxo-1,2,3,6-tetrahydrophthalic anhydride - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 5426-09-5: No information available. Canada CAS# 5426-09-5 is listed on Canada's NDSL List. CAS# 5426-09-5 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 5426-09-5 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A |
| 危害码 (欧洲) | Xi |
|---|---|
| 海关编码 | 2932999099 |
| 海关编码 | 2932999099 |
|---|---|
| 中文概述 | 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途 |
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |