81-60-7

• 常用中文名：1,4,5,8-四羟基蒽醌
• 常用英文名：1,4,5,8-Tetrahydroxy anthraquinone
• CAS号：81-60-7
• 分子式：C₁₄H₈O₆
• 分子量：272.210
• 相关类别： 生物化工 氨基酸及其衍生物 丙氨酸类衍生物
• 发布时间：2018-07-02 19:37:41
• 更新时间：2026-06-30 19:52:40
• 【用途一】
  用作染料中间体
  【用途二】
  抗癌药物米托蒽醌的中间体。

名称

• 中文名: 1,4,5,8-四羟基蒽醌
• 英文名: 1,4,5,8-tetrahydroxyanthraquinone
• 中文别名: 米托蒽醌杂质16; 1,4,5,8-四羟基蒽-9,10-二酮; 1,4,5,8-四羟基-9,10-蒽二酮
• 英文别名: RARECHEM AQ BD AN29; MFCD00428635; 1,4,5,8-Ltoa; 1,4,5,8-tetrahydroxy-10-anthracenedione; 1,4,5,8-tetrahydroxy-anthraquinon; 1,4,5,8-tetrahydroxy-9,10-antraquinone; 1,4,5,8-Tetrahydroxyanthraquinone (Leuco-); Anthraquinone,1,4,5,8-tetrahydroxy; 1,4,5,8-TETRAHYDROXYANTHRAQUINONE; RECHEM AQ BD AN29; 1,4,5,8-tetrahydroxy-anthraquinone; EINECS 201-365-0; Leuco-1,4,5,8-tetrahydrozyanthraguinone; Anthraquinone, 1,4,5,8-tetrahydroxy; 1,4,5,8-Tetrahydroxy Anthraquinone LeucocoMpound; 1,4,5,8-Tetrahydroxy-9,10-anthrachinon; 1,4,5,8-TETRAHYDROXYANTHRACENE-9,10-DIONE; 1,4,5,8-Tetrahydroxy-9,10-anthraquinone; Mitoxantrone Impurity 16; 1,4,5,8-leucotetrahydroxy-9,10-anthracenedione; 1,4,5,8-TETRAHTYDROXYANTHRAQUINONE; 9,10-Anthracenedione, 1,4,5,8-tetrahydroxy; 1,4,5,8-Tetrahydroxyanthrachinon; 1,4,5,8-Tetrahydroxy-9,10-anthracenedione; 1,4,5,8-tetraoxy-9,10-anthraquinone; 1,4,5,8-Leucotetraoxyanthraquinone; 1,4,5,8-Tetrahydroxy-9,10-anthacendione

物化性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 554.8±45.0 °C at 760 mmHg
• 分子式: C₁₄H₈O₆
• 分子量: 272.210
• 闪点: 303.4±25.2 °C
• 精确质量: 272.032074
• PSA: 115.06000
• LogP: 5.55
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.815
• 储存条件: 室温

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CB8070000 CHEMICAL NAME : Anthraquinone, 1,4,5,8-tetrahydroxy- CAS REGISTRY NUMBER : 81-60-7 BEILSTEIN REFERENCE NO. : 2154564 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C14-H8-O6 MOLECULAR WEIGHT : 272.22 WISWESSER LINE NOTATION : L C666 BV IVJ DQ GQ KQ NQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976

安全

• 危害码 (欧洲): Xi

合成路线

上下游产品

上游产品  9
129-44-2 145-49-3 23478-60-6 128-94-9
6374-78-3 14597-12-7 123-31-9 117-10-2
81-55-0
下游产品  1
63229-37-8

制备

【方法一】
以1,8-二羟基蒽醌为原料制取。