107648-80-6

• 常用中文名：盐酸头孢吡肟
• 常用英文名：Cefepime Dihydrochloride
• CAS号：107648-80-6
• 分子式：C₁₉H₂₆Cl₂N₆O₅S₂
• 分子量：553.483
• 相关类别： 原料药 抗生素类药物 头孢菌素类药
• 发布时间：2018-03-30 08:00:00
• 更新时间：2026-07-12 16:30:27
• 盐酸头孢吡肟是一种头孢菌素类抗生素。盐酸头孢吡肟对人血清对氧磷酶-1(hPON1)具有抑制活性,IC50值为21.115 mM[1]。
• 盐酸头孢吡肟为广谱第四代头孢菌素，通过抑制细菌细胞壁的生物合成而达到杀菌作用。体外试验表明，本品对革兰氏阳性菌和阴性菌均有作用。本品对细菌染色体编码的β-内酰胺酶的亲和力低，可高度耐受多数β-内酰胺酶的水解，并可迅速渗入革兰阴性菌的细胞内。在菌体细胞内，其靶分子为青霉素结合蛋白(PBP)。

名称

• 中文名: 盐酸头孢吡肟
• 英文名: Cefeprime dihydrochloride
• 中文别名: 盐酸头孢吡肟一水合物; 头孢吡肟精氨酸混粉; 头孢吡肟盐酸盐; (6R,7R)-7-[[(2E)-2-(2-氨基-1,3-噻唑-4-基)-2-甲氧基亚氨乙酰]氨基]-3-[(1-甲基吡咯烷-1-基)甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸二盐酸盐; 头孢吡肟杂质16; 头孢吡肟精氨酸; 头孢吡肟精氨酸原料; 盐酸头孢吡肟(含精氨酸)
• 英文别名: 1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-(Z-methoxyimino)-acetamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidinium chloride,monohydrochloride; Cefime Dihydrochloride : L(+)-ginine; l-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)-glyoxylamido]-2-carboxy-8-oxo-5-thia-l-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidinium chloride; Cefime DiHCl; (6R,7R)-7-[[(2E)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid chloride hydrochloride; CEFIME HCL STERILE POWDER; CefiMe hydrochloric; (6R,7R)-7-[[(2Z)-(2-Aminothiazol-4-yl)(methoxy-imino)acetyl]amino]-3-[1-methylpyrrolidinio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylate dihydrochloride; CEFRIME DIHYDROCHLORIDE; 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-cboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidinium chloride hydrochloride; cefepime dihydrochloride; Cefime Hydrochloride with ginine; Cefime Impurity 16; MFCD06795759; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate dihydrochloride; Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, chloride, hydrochloride (1:1:1); CEFEPIME HCL STERILE POWDER; Cefrime dihydrochloride //BP; PyrrolidiniuM,1-[[(6R,7R)-7-[[(2Z)-2-(2-aMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]-1-Methyl-,chloride,hydrochloride (1:1:1; 1-(((6R,7R)-7-((Z)-2-(2-aMinothiazol-4-yl)-2-(MethoxyiMino)acetaMido)-2-cboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)Methyl)-1-Methylpyrrolidin-1-iuM chloride hydrochloride; Cefime Hydrochloride/ginine; CEFIME HCL; PyrrolidiniuM,1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(MethoxyiMino)acetyl]amino]-2-cboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]-1-Methyl-,chloride, hydrochloride (1:1:1; CEFEPIME HCL; CefepiMe hydrochloric; Cefime Hydrochlorede; Cefime dihydrochloride(L-ginine) Sterile; 1-{[(6R,7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidinium chloride hydrochloride (1:1:1); CEFIME DIHYDROCHLORIDE; 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidinium chloride hydrochloride; (6R,7R)-7-[[(2E)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid chloride hydrochloride; TIANFU CHEM- Cefrime dihydrochloride; pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, inner salt, hydrochloride (1:2); PyrrolidiniuM,1-[[(6R,7R)-7-[[(2Z)-2-(2-aMino-4-thiazolyl)-2-(Me

物化性质

• 熔点: 150ºC (dec.)
• 分子式: C₁₉H₂₆Cl₂N₆O₅S₂
• 分子量: 553.483
• 精确质量: 552.078308
• PSA: 203.58000
• LogP: 1.19290

生物活性

• 描述: 盐酸头孢吡肟是一种头孢菌素类抗生素。盐酸头孢吡肟对人血清对氧磷酶-1(hPON1)具有抑制活性,IC50值为21.115 mM[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Türkeş C, et al. Human serum paraoxonase-1 (hPON1): in vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium. J Enzyme Inhib Med Chem. 2015;30(4):622-8.

安全

• 海关编码: 2941905990

海关

海关编码	2941905990