165049-28-5

• 常用中文名：N-(4-[2-(2-氨基-4,7-二氢-4-氧-1H-吡咯[2,3-D]嘧啶-5-基)乙基]苯甲酰)-L-谷氨酸二乙酯对甲苯磺酸盐
• 常用英文名：Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 4-methylbenzenesulfonate
• CAS号：165049-28-5
• 分子式：C₃₁H₃₇N₅O₉S
• 分子量：655.719
• 相关类别： 生物化工 氨基酸及其衍生物 谷氨酸类衍生物
• 发布时间：2018-06-13 15:55:47
• 更新时间：2026-07-16 19:33:29

名称

• 中文名: N-[4-[2-(2-氨基-4,7-二氢-4-氧代-1H-吡咯并[2,3-d]嘧啶-5-基)乙基]苯甲酰]-L-谷氨酸二乙酯对甲苯磺酸盐
• 英文名: diethyl (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate,4-methylbenzenesulfonic acid
• 中文别名: 培美曲塞二钠中间体V; 培美曲塞二钠中间体五; (S)-2-(4-(2-(2-氨基-4-氧代-4,7-二氢-3H-吡咯并[2,3-D]嘧啶-5-基)乙基)苯甲酰胺基)戊二酸二乙酯4-甲基苯磺酸盐; 培美曲塞二钠中间体2; N-[4-[2-(2-氨基-4,7-二氢-4-氧代-1H-吡咯并[2,3-D]嘧啶-5-基)乙基]苯甲酰]-L-谷氨酸二乙酯对甲苯磺酸盐; 培美曲塞杂质30(对甲苯磺酸盐); N-[4-[2-(2-氨基-4,7-二氢-4-OXO-1H-吡咯[2,3-D]嘧啶-5-基)乙基]苯甲酰]-L-谷氨酸二乙基酯4-甲苯磺酸; 培美曲塞二乙酯; N-[4-[2-(2-氨基-4,7-二氢-4-氧代-1H-吡咯并[2,3-D]嘧啶-5-基)乙基]苯甲酰]-L-谷氨酸二乙酯对甲苯磺酸盐(培美曲塞二钠中间体); N-[4-[2-(2-氨基-4,7-二氢-4-氧代-1H-吡咯并[2,3-D]嘧啶-5-基)乙基]苯甲酰]-L-谷氨酸二乙酯对甲苯磺酸盐(培美曲塞二钠中间体V); N-(4-[2-(氨基-4,7-二氢-4-氧-1H-吡咯[2,3-D]嘧啶-5-基)乙基]苯甲酰)-L-谷氨酸二乙酯对甲苯磺酸盐; 培美曲塞二钠中间体五 N-[4-[2-(2-氨基-4,7-二氢-4-氧代-1H-吡咯并[2,3-D]嘧啶-5-基)乙基]苯甲酰]-L-谷氨酸二乙酯对甲苯磺酸盐; N-[4-[2-(2-氨基-4,7-二氢-4-氧-3H-吡咯[2,3-D]嘧啶-5-基)乙基]苯甲酰]-L-谷氨酸1,5-二乙酯4-甲基苯磺酸; (S)-二乙基 2-(4-(2-(2-氨基-4-羰基-4,7-二氢-3H-吡咯并[2,3-D]嘧啶-5-基)乙基)苯甲酰胺基)戊烷二酸酯 4-甲基苯磺酸酯; N-(4-[2-(2-氨基-4,7-二氢-4-氧-3H-吡咯[2,3-d]嘧啶-5-基)乙基]苯甲酰)-L-谷氨酸二乙酯对甲苯磺酸盐; 培美曲塞二钠中间体2/N-[4-[2-(2-氨基-4,7-二氢-4-氧代-1H-吡咯并[2,3-D]嘧啶-5-基)乙基]苯甲酰]-L-谷氨酸二乙酯对甲苯磺酸盐; N-(4-[2-(2-氨基-4,7-二氢-4-氧-1H-吡咯[2,3-D]嘧啶-5-基)乙基]苯甲酰)-L-谷氨酸二乙; 培美曲塞杂质20(培美曲塞二乙酯); N-(4-[2-(2-氨基-4,7-二氢-4-氧-3H-吡咯[2,3-D]嘧啶-5-基)乙基]苯甲酰)-L-谷氨酸二乙酯对甲苯磺酸盐
• 英文别名: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate; Pemetrexed Impurity 30(p-toluene sulfonate); diethyl N-( {4-[2-(2-amino-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)]phenyl}carbonyl)-L-glutamate 4-methylbenzenesulfonate; N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate //BP; N - [4- [2- (2-amino-4,7-dihydro-4-oxo-1H-pyrrolo [2,3-d] pyrimidin-5-yl) ethyl] benzoyl] - L-glutamic acid diethyl ester p-toluenesulfonate; pentanedioate 4-methylbenzenesulfonate; (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pe; Cvedilol Impurity 38; PeMetrexed disodiuM INT-5; (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 4-methylbenzenesulfonate; 5-[2-(4-{[(2S)-1,5-Diethoxy-1,5-dioxo-2-pentanyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium 4-methylbenzenesulfonate; N-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-1H-Pyrrolo[2,3-D]Pyrimidin-5-yl)Ethyl]Benzoyl]-L-Glutamic Acid Diethyl Ester 4-Toluene Sulfonate; pemetrexed dimethyl ester; L-Glutamic acid,N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, diethyl ester, mono(4-methylbenzenesulfonate); N-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-3h-Pyrrolo[2,3- D]Pyrimidin-5-Yl)Ethyl]Benzoyl]-L-Glutamic Acid-1,5-Diethyl Ester 4-Ethylbenzene Sulfonate; (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido; Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl); )benzamido)pentanedioate 4-methyL; L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, 1,5-diethyl ester, 4-methylbenzenesulfonate (1:1); 5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycbonyl)-4-oxobutyl]cbaMoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-2-aMiniuM 4-Methylbenzenesulfonate (non-preferred naMe); N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3; 5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycbonyl)-4-oxobutyl]cbam; etrexed Impurity 30(4-Methylbenzenesulfonate); (S)-DiethyL; iethyl(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate,4-methylbenzenesulfonicaci; N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-glutaMic acid; N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-dimethyl ester 4-methylbenzenesulfonate; D-Pemetrexed Dimethyl Diester; (2S)-2-{[4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid; N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid, 1; 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrroL; benzamido); N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-glutaMic acid, 1,5-diethyl ester, 4-Methylbenzenesulfonate (1:1); Pemetrexed Methyl Ester

物化性质

• 分子式: C₃₁H₃₇N₅O₉S
• 分子量: 655.719
• 精确质量: 655.231201
• PSA: 232.01000
• LogP: 4.91800
• 储存条件: 室温，避光，保存于惰性气体中

安全

• 海关编码: 2942000000

合成路线

137281-39-1 ~% 165049-28-5

文献：Organic Process Research and Development, , vol. 3, # 3 p. 184 - 188

106200-41-3 ~% 165049-28-5

文献：Organic Process Research and Development, , vol. 3, # 3 p. 184 - 188

123910-86-1 ~% 165049-28-5

文献：Organic Process Research and Development, , vol. 3, # 3 p. 184 - 188

619-42-1 ~% 165049-28-5

文献：Organic Process Research and Development, , vol. 3, # 3 p. 184 - 188

123910-88-3 ~% 165049-28-5

文献：Organic Process Research and Development, , vol. 3, # 3 p. 184 - 188

104-15-4 146943-43-3 ~% 165049-28-5

文献：Barnett, Charles J.; Wilson, Thomas M.; Kobierski, Michael E. Organic Process Research and Development, 1999 , vol. 3, # 3 p. 184 - 188

1209465-70-2 ~% 165049-28-5

文献：Organic Process Research and Development, , vol. 9, # 6 p. 738 - 742

上下游产品

上游产品  8
137281-39-1 106200-41-3 123910-86-1 619-42-1
123910-88-3 104-15-4 146943-43-3 1209465-70-2
下游产品  1
137281-23-3

海关

海关编码	2942000000