66332-96-5

• 常用中文名：氟酰胺
• 常用英文名：FLUTOLANIL
• CAS号：66332-96-5
• 分子式：C₁₇H₁₆F₃NO₂
• 分子量：323.31000
• 相关类别： 化学农药原药 杀菌剂 其他杀菌剂
• 发布时间：2018-09-01 13:33:00
• 更新时间：2026-07-01 12:02:30
• 属苯甲酰胺衍生物，具有预防和治疗作用的内吸性杀菌剂。用于防治某些担子菌纲真菌。对菌丝的生育和侵入菌丝块的形成具有很强的阻碍作用。如防治丝核菌引起的水稻纹枯病，以50mg/L浓度茎叶处理，防治效果100%。
  用途 内吸杀菌剂，对水稻纹枯病，马铃薯黑痣病等有效。

名称

• 中文名: 氟酰胺
• 英文名: flutolanil
• 中文别名: 甲苯中氟酰胺; 氟酰胺溶液, 1000PPM; 标准物质/甲醇中氟酰胺; N-(3’-异丙氧基苯基)-2-三氟甲基苯甲酰胺; 氟担菌宁 标准品; 氟担菌宁,N-(3'-异丙氧基苯基)-2-三氟甲基苯甲酰胺; 纹枯胺; 甲醇中氟酰胺(纹枯胺)标准品; 甲苯中氟酰胺(纹枯胺)标准品; 氟担菌宁; 甲苯中氟酰胺溶液,1000ΜG/ML; 纹枯胺 (氟酰胺) 标准品; 化合物：Flutolanil; 氟纹胺; 化合物:Flutolanil; 氟酰胺(标准品); 丙酮中氟酰胺溶液标准物质; 甲醇中氟酰胺溶液标准物质; 纹枯胺/氟酰胺; 望佳多; 3'-异丙氧基-2-(三氟甲基)苯甲酰苯胺; 纹枯胺 标准品; 甲醇中氟酰胺; 乙腈中氟酰胺; 甲醇中氟酰胺-纹枯胺; 氟酰胺(纹枯胺)检测标准品
• 英文别名: N-[3-(Isopropyloxy)phenyl]-2-(trifluoromethyl)benzamide; Flutolanil@1000 μg/mL in Acetone; o-trifluoromethyl-m'-isopropoxybenzoic anilide; α,α,α-trifluoro-3'-isopropoxy-o-toluanilide; Flutolanil 250mg [66-5]; N-[3-(propan-2-yloxy)phenyl]-2-(trifluoromethyl)benzamide; Flutolanil 10 μg/mL in Cyclohexane; Prostar; MONCUT; Flutolanil in Acetonitrile; Flutalanil; n-(3-(1-methylethoxy)phenyl)-2-(trifluoromethyl)benzamide; N-(3-propan-2-yloxyphenyl)-2-(trifluoromethyl)benzamide; N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)benzamide; Folistar; FLUTOLANIL STANDD; 3'-isopropoxy-2-trifluoromethyl benzoic acid anilide; Flutolanil @100 μg/mL in MeOH; A,A,A-TRIFLUORO-3'-ISOPROPOXY-O-TOLUANILIDE; FlutolanilSolution,1,000mg/L; Flutolanil Reference Material; Flutolanil in Methanol; NNF-136; Moncut; Flutolanil 0.1; n-(3-(1-methylethoxy)phenyl)-2-(trifluoromethyl)-benzamid; MONCUT(R); C13863500 Flutolanil; 3'-Isopropoxy-2-trifluoromethylbenzanilide; Flutolanil 10.0 μg/ml Ethyl acetate; flutolanil (bsi,draft e-iso,draft f-iso); Flutolanil Solution, 1000ppm; Flutolanil Solution in Toluene, 1000μg/mL; Flufenacet Impurity 3; 3'-isopropoxy-2-trifloromethyl benzoic acid anilide; Flutolanil [BSI:ISO]; FLUTOLANIL, 250MG, NEAT; Flutolanil 100 μg/ml Acetonitrile; α,α,α-trifluoro-3’-isopropoxy-o-toluanilide; N-(3-Isopropoxyphenyl)-2-(trifluoromethyl)benzamide; Flutolanil Solution in Methanol; alpha,alpha,alpha-trifluoro-3’-isopropoxy-o-toluanilide

物化性质

• 密度: 1.247g/cm3
• 沸点: 339.1ºC at 760 mmHg
• 熔点: 108° (Araki, Yabutani); mp 104-105° (Araki, 1985)
• 分子式: C₁₇H₁₆F₃NO₂
• 分子量: 323.31000
• 闪点: 158.9ºC
• 精确质量: 323.11300
• PSA: 38.33000
• LogP: 4.81790
• 折射率: 1.543
• 储存条件:

  2-8 ºC保存。

• 分子结构:

  1、 摩尔折射率：81.71

  2、 摩尔体积（cm³/mol）：259.2

  3、 等张比容（90.2K）：637.7

  4、 表面张力（dyne/cm）：36.6

  5、 极化率（10^-24cm³）：32.39

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:5

  4.可旋转化学键数量:4

  5.互变异构体数量:2

  6.拓扑分子极性表面积38.3

  7.重原子数量:23

  8.表面电荷:0

  9.复杂度:398

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：白色结晶。

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：102～103

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：1.77×10^-9

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定。

毒性和生态

毒理学数据: 1、急性毒性：大鼠（口服）LD50： 10 mg/kg 大鼠（皮上）LD50： ＞5mg/kg 大鼠（腹膜）LD50： ＞10mg/kg 大鼠（皮下）LD50： ＞10mg/kg 小鼠（腹膜）LD50： ＞10mg/kg 小鼠（皮下）LD50： ＞10mg/kg 由于食盐的LD50是3,000 mg/kg，BPA的急性毒性程度与食盐同。 CHEMICAL IDENTIFICATION RTECS NUMBER : CV5581320 CHEMICAL NAME : Benzamide, N-(3-(1-methylethoxy)phenyl)-2-(trifluoromethyl)- CAS REGISTRY NUMBER : 66332-96-5 LAST UPDATED : 199701 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C17-H16-F3-N-O2 MOLECULAR WEIGHT : 323.34 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C209,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),23,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,153,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,153,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,426,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,153,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,153,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18 gm/kg/30D-C TOXIC EFFECTS : Liver - other changes Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,153,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 438 gm/kg/2Y-C TOXIC EFFECTS : Liver - other changes Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,153,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 913 gm/kg/2Y-I TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from duodenum Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,153,1988

安全

• 危害码 (欧洲): F+
• RTECS号: CV5581320
• 危险类别: 3，6.1
• 海关编码: 2924299033

合成路线

41406-00-2 312-94-7 ~91% 66332-96-5

文献：Nihon Nohyaku Co., Ltd. Patent: US4093743 A1, 1978 ;

上下游产品

上游产品  2
41406-00-2 312-94-7
下游产品  5
360-64-5 134314-54-8 433-97-6 69392-32-1
134314-55-9

制备

制备方法一
邻三氟甲基苯甲酰氯可用邻三氟甲基氯苯为原料，经过格氏反应，然后与干冰反应羰基化，再经水解得邻三氟甲基苯甲酸，该酸经酰氯化制得邻三氟甲基苯甲酰氯。邻三氟甲基苯甲酰氯在冰冷却下，加到四氢呋喃中，在三乙胺存下及室温下，与间异丙氧基苯胺反应2h，得氟担菌宁。
制备方法二
氟担菌宁也可通过3-（2-三氟甲基苯甲酰氨基）苯酚与2-氯代丙烷反应制得。

海关

海关编码	2924299033
中文概述	2924299033 庚酰草胺、环丙草胺、环酰草胺、氟虫隆等〔包括氟虫脲、氟铃脲、氟酰胺、氟蚁灵、氟幼脲〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
监管条件	S.进出口农药登记证明
Summary	2924299033 2,6-difluoro-n-((4-(trifluoromethyl)phenyl)carbamoyl)benzamide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%