6484-89-5

• 常用中文名：sodium folate
• 常用英文名：sodium folate
• CAS号：6484-89-5
• 分子式：C₁₉H₁₈N₇NaO₆
• 分子量：463.37900
• 相关类别： 信号通路 细胞周期/DNA损伤 DNA/RNA合成
• 发布时间：2017-03-06 19:50:16
• 更新时间：2024-01-07 12:48:22
• 叶酸(维生素B9)钠是一种口服活性必需营养素,来自B族复合维生素。叶酸钠具有抗抑郁作用。叶酸钠可降低新生儿神经管缺陷的风险。叶酸钠可用于治疗因叶酸缺乏引起的巨幼细胞和大细胞贫血[1][2][3][4]。

名称

• 英文名: sodium folate

物化性质

• 分子式: C₁₉H₁₈N₇NaO₆
• 分子量: 463.37900
• 精确质量: 463.12200
• PSA: 216.11000

生物活性

• 描述: 叶酸(维生素B9)钠是一种口服活性必需营养素,来自B族复合维生素。叶酸钠具有抗抑郁作用。叶酸钠可降低新生儿神经管缺陷的风险。叶酸钠可用于治疗因叶酸缺乏引起的巨幼细胞和大细胞贫血[1][2][3][4]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 神经疾病
• 靶点:

  Microbial Metabolite

• 体外研究: 叶酸钠在防止染色体断裂和DNA低甲基化方面起着关键作用[1]。
• 体内研究: 叶酸钠(10、50、100 mg/kg；p.o.)在该行为小鼠模型中显示出抗抑郁作用[2]。叶酸钠(1,10 nmol/位点)在习惯于新环境的小鼠中没有显示出精神刺激作用[2]。叶酸钠(1,5 mg/kg；p.o.)可防止大鼠后代肝脏基因表达的表观遗传修饰[3]。动物模型：30-40 g瑞士小鼠[2]剂量：10、50、100 mg/kg给药：P.o.结果：减少强迫游泳试验(FST)中的不动时间(F324=11.21),并对尾部悬吊试验(TST)中不动时间产生显著影响(F3,20=5.71)。动物模型：30-40g瑞士小鼠[2]剂量：1-10nmol/部位给药：静脉注射。结果：减少小鼠在FST(F3,22=12.31)和TST(F33,22=5.50)中的不动时间。动物模型：处女雌性Wistar大鼠[3]剂量：1,5 mg/kg(180 g/kg蛋白质加1 mg/kg叶酸或90 g/kg酪蛋白加1,5 g/kg叶氨酸)给药：P.o.结果：预防表观生长
• 参考文献:

  [1]. Butterworth CE Jr, et al. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8.

  [2]. Brocardo PS, et al. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73.

  [3]. Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6.

  [4]. Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LP5700000 CHEMICAL NAME : Folic acid, monosodium salt CAS REGISTRY NUMBER : 6484-89-5 LAST UPDATED : 198909 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C19-H18-N7-O6.Na MOLECULAR WEIGHT : 463.43 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 526 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 48,289,1946 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 631 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 48,289,1946 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 431 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 48,289,1946 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 126 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 48,289,1946