15401-69-1

• 常用中文名：小檗红碱
• 常用英文名：Berberrubine
• CAS号：15401-69-1
• 分子式：C₁₉H₁₆ClNO₄
• 分子量：357.788
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-08-27 15:10:53
• 更新时间：2024-01-02 19:31:51
• Berberrubine chloride 是黄连素的有效代谢物,可降低动物模型中溃疡性结肠炎的症状。

名称

• 中文名: 小檗红碱
• 英文名: berberrubine, hydrochloride, dihydrate
• 英文别名: berberoline chloride; berberrubine; 2,3-methylenedioxy-9-hydroxy-10-methoxyprotoberberine chloride; Berberrubine chloride; 5,6-Dihydro-9-hydroxy-10-methoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride; 9-Hydroxy-10-methoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride; Beroline chloride; berberrubine hydrochloride; beberrubine chloride; 9-Demethoxy-9-hydroxyberberinium chloride; Chileninone; hydrochloride berberrubine; Berberubine hydrochloride; 1,3-Benzodioxolo[5,6-a]benzo[g]quinolizinium, 5,6-dihydro-9-hydroxy-10-methoxy-, chloride (1:1); 9-Berberoline chloride

物化性质

• 熔点: 245℃ (DEC.)
• 分子式: C₁₉H₁₆ClNO₄
• 分子量: 357.788
• 精确质量: 357.076782
• PSA: 51.80000
• 蒸汽压: 4.28E-15mmHg at 25°C
• 折射率: 1.724
• 储存条件: 2-8C

生物活性

• 描述: Berberrubine chloride 是黄连素的有效代谢物,可降低动物模型中溃疡性结肠炎的症状。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Yu XT, et al. Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice. PLoS One. 2018 Mar 14;13(3):e0194069.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DE5399000 CHEMICAL NAME : Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9-hydroxy-10-methoxy-, chloride CAS REGISTRY NUMBER : 15401-69-1 LAST UPDATED : 199009 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C19-H16-N-O4.Cl MOLECULAR WEIGHT : 357.81 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 22,856,1988

合成路线

633-65-8 ~10% 15401-69-1

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 7 p. 1762 - 1765

108275-17-8 ~92% 15401-69-1

文献：Pharmaceutical Chemistry Journal, , vol. 22, # 11 p. 856 - 857 Khimiko-Farmatsevticheskii Zhurnal, , vol. 22, # 11 p. 1348 - 1349

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