571188-82-4

• 常用中文名：4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶基]-1-哌嗪羧酸叔丁酯
• 常用英文名：4-[6-[(6-Bromo-8-cyclopentyl-7,8-dihydro-5-methyl-7- oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1- piperazinecarboxylic acid 1,1-dimethylethyl ester
• CAS号：571188-82-4
• 分子式：C₂₇H₃₄BrN₇O₃
• 分子量：584.508
• 发布时间：2018-12-12 17:52:17
• 更新时间：2026-07-05 10:21:39

名称

• 中文名: 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶基]-1-哌嗪羧酸叔丁酯
• 英文名: tert-butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-carboxylate
• 中文别名: 帕布昔利布标准品016; 帕博西尼布杂质18; 帕博西尼杂质72; (3E)-1-(2-氯乙酰基)-2,3-二氢-3-(甲氧基苯基亚甲基)-2-氧代-1H-吲哚-6-羧酸甲酯; 帕布西利布中间体1; 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基); 帕博西林中间体3; 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶/571-4; 2-[[5-(4-BOC-1-哌嗪基)-2-吡啶基]氨基]-5-甲基-6-溴-8-环戊基吡啶并[2,3-D]嘧啶-7(8H)-酮; 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶基]-1-哌嗪羧酸叔丁酯(帕布昔利布中间体); 哌柏西利杂质72; 4-[6-(6-溴-8-环戊基-5-甲基-7-氧代-7,8-二氢吡啶并[2,3-D]嘧啶- 2-基氨基)-吡啶-3-基]-哌嗪-1-羧酸叔丁酯; 帕布昔利布杂质23; 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶(帕布昔利布杂质); 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶基; 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶; 帕布昔利布中间体1; PALBOCICLIB中间体 PB-4; 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶基]-1-哌嗪羧酸叔丁酯 哌泊塞克雷布中间体; 帕博西尼杂质I; 帕布昔利布中间体6; 帕布昔利布中间体1/A; 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[; 帕布昔利布(帕博西尼)杂质72; PALBOCICLIB中间体2; 帕布昔利布中间体一; 哌柏西利 INT1; RIBOCICLIB(PALBOCICLIB)中间体1; 帕布昔利布24
• 英文别名: Palbociclib impurity 18/4-[6-[(6-Bromo-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinecboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl); 2-Methyl-2-propanyl 4-{6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-1-piperazinecarboxylate; tert-butyl 4-{6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-d; Palbociclib Intermediate 4; 6-Bromo-8-cyclopentyl-2-[[5-(4-Boc-1-piperazinyl)-2-pyridyl]amino]-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one; (6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO- PYRIDO[2,3-D]PYRIMIDIN-2-YLAMIINO)-PYRIDIN-3-YL]-PIPERAZINE-1- CBOxYLICACID TERT-BUTYLESTER; 1-Piperazinecboxylic acid, 4-[6-[(6-broMo-8-cyclopentyl-7,8-dihydro-5-Methyl-7-oxopyrido[2,3-d]pyriMidin-2-yl)amino]-3-pyridinyl]-, 1,1-diMethylethyl ester; Pabucil intermediate; tert-butyl 4-{6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl}piperazine-1-cboxylat; 4- [6- (6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido [2,3-d] pyrimidin -2- ylamino) - pyridine 3-yl] - piperazine-1- cboxylic acid tert-butyl ester; 1-Piperazinecarboxylic acid, 4-[6-[(6-bromo-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-, 1,1-dimethylethyl ester; 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CBOXYLIC ACID TERT-BUTYL ESTER; 4-[6-[(6-Bromo-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinecboxylic acid 1,1-dimethylethyl ester; tert-butyl 4-[6-({6-bromo-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazine-1-cboxylate; Palbociclib-016; tert-butyl 4-{6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl}piperazine-1-carboxylate; tert-butyl 4-(6-(6-bromo-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-cboxylate; 1-Piperazinecarboxylic acid,4-[6-[(6-bromo-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-,1,1-dimethylethyl ester; tert-butyl 4-(6-((6-broMo-8-cyclopentyl-5-Methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyriMidin-2-yl)amino)pyridin-3-yl)piperazine-1-cboxylate; tert-Butyl-4-{6-[(6-brom-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl}piperazin-1-carboxylat; tert-butyl 4-[6-({6-bromo-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyrid; 4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester; 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO; ter-butyl-4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-cboxylate; MFCD09834002; 4-{6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)]-pyridin-3-yl}-piperazine-1-cboxylic acid-butyl ester; Palbociclib Impurity 72; 4-[6-[(6-Bromo-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-tert-Butyl piperazine-1-cboxylate; tert-butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-cboxylate

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 720.0±70.0 °C at 760 mmHg
• 分子式: C₂₇H₃₄BrN₇O₃
• 分子量: 584.508
• 闪点: 389.3±35.7 °C
• 精确质量: 583.190613
• PSA: 105.48000
• LogP: 2.95
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.647
• 储存条件: 2~8℃

安全

• 危害码 (欧洲): Xn

合成路线

571188-81-3 571188-59-5 ~37% 571188-82-4

文献：Barvian, Mark; Booth, Richard John; Ouin III, John; Thomas Repine, Joseph; Sheehan, Derek J.; Toogood, Peter Laurence; Vanderwel, Scott Norman; Zhou, Hairong Patent: US2003/149001 A1, 2003 ; US 20030149001 A1

775288-71-6 ~% 571188-82-4

文献：Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W. Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406

571189-16-7 ~% 571188-82-4

文献：Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W. Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406

39856-50-3 ~% 571188-82-4

文献：Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W. Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406

362656-25-5 ~% 571188-82-4

文献：Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W. Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406

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