571188-59-5

• 常用中文名：4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯
• 常用英文名：tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
• CAS号：571188-59-5
• 分子式：C₁₄H₂₂N₄O₂
• 分子量：278.350
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-12-17 17:41:21
• 更新时间：2026-08-02 16:16:44

名称

• 中文名: 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯
• 英文名: tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
• 中文别名: 帕布昔利布POB02; 帕布昔利布中间体 PB-2; 4-(6-氨基-吡啶-3-基)-哌嗪-1-羧酸叔丁基; 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯(帕布昔利布中间体); 叔丁基4 -(6 -氨基吡啶-3 -基)哌嗪-1 -羧酸叔丁酯; 帕布昔利布标准品018; 4-(6-氨基-3-吡啶基)哌嗪-1-甲酸叔丁酯*5; 4-(6-氨基-3-吡啶基)哌嗪-1-羧酸叔丁脂; 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯(片段B); 帕博西林中间体5; 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯 哌泊塞克雷布中间体; 叔丁基4-(6-氨基吡啶-3-基)哌嗪-1-羧酸酯; 瑞博西尼、帕布昔利布中间体; 博西尼杂质68; (6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯; 1-BOC-4-(6-氨基-3-吡啶基)哌嗪; 帕布昔利布杂质68; 帕布昔利布(帕博西尼)杂质68; 瑞博西尼杂质2; 1-BOC-4-(6-氨基吡啶-3-基)哌嗪; PALBOCICLIB中间体POB02; 4-(6-氨基吡啶-3; 1-Boc-4-(6-氨基-3-吡啶基)哌嗪; 4-(6-氨基吡啶; 4-(6-氨基吡啶-3-基)哌嗪; 4-(6-氨基-3-吡啶基)-1-BOC-哌嗪; 叔-丁基 4-(6-氨基吡啶-3-基)哌嗪-1-甲酸基酯; 帕布昔利布中间体1; 瑞博西尼RIBOCICLIB中间体; 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯(帕博西布中间体); 帕布昔利布中间体4; 叔丁基酯; 帕博西尼杂质68; 瑞博西尼中间体2; 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯 PALBOCICLIB中间体; 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁脂(帕布昔利布中间体); 哌柏西利杂质68; 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁脂(帕布昔利; BOC-4-(6-氨基吡啶-3-基)哌嗪; 4-(6-氨基-3-吡啶基)哌嗪-1-甲酸叔丁酯; 1-BOC-4-(6-氨基-3-吡啶基)哌嗪(帕布昔利布中间体); 4-(6-氨基-吡啶-3-基)-哌嗪-1-羧酸叔丁基酯; 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯,4-(6-氨基-3-吡啶基)哌嗪-1-甲酸叔丁酯; PALBOCICLIB中间体4; 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯帕博塞布
• 英文别名: 4-(6-AMinopyridin-3-yl)-1-Boc-piperazin; 4- (6-aminopyridine-3-yl) piperazin-1-cboxylic acid tert-butyl ester; OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine(571-5); tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate; 1-(tert-Butoxycbonyl)-4-(6-aminopyridin-3-yl)piperazine; 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate); Tert-buty 4-(6-amino-3-pyridyl)piperazine-1-cboxylate; 4-(6-aMinopyridin-3-yl)p; TERT BUTYL-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE-1-CARBOXYLATE; 1-Boc-4-(6-amino-3-pyridyl)piperazine; 6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected; Ribociclib Intermediate 4; 4-(6-Aminopyridin-3-yl)piperazine-1-cboxylic acid tert-butyl ester; 4-(6-aminopyridin-3-yl)piperazine-1-cboxylate; Palbociclib Impurity 68; 4-(6-aminopyridine-3-yl) piperazine-1-cboxylic tert-butyl ester; 4-(6-Amino-3-pyridyl)-1-Boc-piperazine; OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine; Ribociclib-2; tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-cboxylate(For Palbociclib); Tert-Butyl 4-(6-aminopyridin-3-piperazine-1-cboxylate; 1-tert-Butoxycbonyl-4-(6-amino-3-pyridyl)piperazine; 4-(6-Amino-3-pyridyl)piperazine-1-cboxylic Acid tert-Butyl Ester; PALBOCICLIB4; 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate; tert-butyl 4-(6-aminoyridin-3-yl)pipera-zine-1-cboxylate; tert-Butyl-4-(6-aminopyridin-3-yl)piperazin-1-cboxylate; Palbociclib-11; 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZIN; Palbociclib Intermediate; ert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-cboxylate; Palbociclib's intermediate; tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-cboxylate; 1-Butyloxycbonyl-4-(6-aminopyridin-3-yl)-piperazine; Ribociclib Related Compound 1; 4-(6-AMinopyridin-3-yl)-1-Boc-piperazine; )piperazine-1-cboxyL; 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE; 1-Piperazinecboxylic acid, 4-(6-amino-3-pyridinyl)-, 1,1-diMethylethyl ester; tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-cboxylate; Palbociclib Intermediate 1, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-cboxylate; Palbociclib-018; 4-(6-aMinopyridin-3-yl)piperazine-1-cboxylic; Tert-Butyl 4-(6-Amino-3-Pyrimidin)Piperazine-1-Cboxylate; 4-(6- aminopyridine -3- yl) piperazine -1- tert-butyl cboxylate; tert-butyl 4-(6-aMinopyri; POB02; OTAVA-BB; tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-cboxylate >; 2-Methyl-2-propanyl 4-(6-amino-3-pyridinyl)-1-piperazinecboxylate; OTAVA-BB 1207229 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-cboxylate; Palbociclib side chain; tert-Butyl-4-(6-aminopyridin-3-yl)piperazin-1-carboxylat; t-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-cboxylate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 454.1±45.0 °C at 760 mmHg
• 熔点: 130-132℃
• 分子式: C₁₄H₂₂N₄O₂
• 分子量: 278.350
• 闪点: 228.4±28.7 °C
• 精确质量: 278.174286
• PSA: 71.69000
• LogP: 1.23
• 外观性状: 固体;White to Yellow to Green powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.569
• 储存条件: 2~8℃

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

571189-16-7 ~99% 571188-59-5

文献：Imaeda, Yasuhiro; Kawamoto, Tetsuji; Tobisu, Mamoru; Konishi, Noriko; Hiroe, Katsuhiko; Kawamura, Masaki; Tanaka, Toshimasa; Kubo, Keiji Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 3125 - 3140

39856-50-3 ~% 571188-59-5

文献：Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2388 - 2406

775288-71-6 ~% 571188-59-5

文献：Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2388 - 2406

57260-71-6 ~% 571188-59-5

文献：WO2011/140488 A1, ; WO 2011/140488 A1

24424-99-5 ~% 571188-59-5

文献：US2012/115878 A1, ;

21717-96-4 ~% 571188-59-5

文献：WO2012/97682 A1, ;

779345-37-8 ~% 571188-59-5

文献：WO2012/97682 A1, ;

上下游产品

上游产品  7
571189-16-7 39856-50-3 775288-71-6 57260-71-6
24424-99-5 21717-96-4 779345-37-8
下游产品  3
733038-80-7 571188-82-4 571189-03-2

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%