606-04-2

• 常用中文名：帕马溴
• 常用英文名：Pamabrom
• CAS号：606-04-2
• 分子式：C₁₁H₁₈BrN₅O₃
• 分子量：348.19600
• 相关类别： 分析化学 分析试剂 离子色谱试剂
• 发布时间：2018-03-23 08:00:00
• 更新时间：2024-01-02 12:28:53
• Pamabron是利尿剂,可缓解月经相关症状,其有效成分为8-bromotheophylline。

名称

• 中文名: 帕马溴
• 英文名: 2-amino-2-methylpropan-1-ol,8-bromo-1,3-dimethyl-7H-purine-2,6-dione
• 中文别名: 2-氨基-2-甲基丙醇 8-溴胆茶碱
• 英文别名: Predema; 2-amino-2-methylpropanol 8-bromotheophyllinate; Premsyn PMS; EINECS 210-103-4; Pamabrom|; MFCD00867328; 8-bromo-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione; 8-Brom-1,3-dimethyl-3,7-dihydro-purin-2,6-dion,Verbindung mit 2-Amino-2-methyl-propan-1-ol; 8-bromo-1,3-dimethyl-3,7-dihydro-purine-2,6-dione,compound with 2-amino-2-methyl-propan-1-ol; UNII-UA8U0KJM72; Sunril; Pamabrom

物化性质

• 沸点: 469.5ºC at 760 mmHg
• 熔点: >300ºC
• 分子式: C₁₁H₁₈BrN₅O₃
• 分子量: 348.19600
• 闪点: 237.7ºC
• 精确质量: 347.05900
• PSA: 118.93000
• LogP: 0.13910
• 外观性状: 白色-类白色晶体-粉末
• 储存条件: Refrigerator

生物活性

• 描述: Pamabron是利尿剂,可缓解月经相关症状,其有效成分为8-bromotheophylline。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
• 参考文献:

  [1]. Ortiz MI, Rangel-Flores E, Carrillo-Alarcón LC, et al. Prevalence and impact of primary dysmenorrhea among Mexican high school students. Int J Gynaecol Obstet. 2009 Dec;107(3):240-3.

  [2]. Swanson JK, English JC 3rd. Serum sickness-like reaction to Pamabrom. J Drugs Dermatol. 2006 Mar;5(3):284-6.

  [3]. Di Girolamo G, Sánchez AJ, De Los Santos AR, et al. Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea? Expert Opin Pharmacother. 2004 Mar;5(3):561-70.

  [4]. Pamabrom

MSDS

Section 1. Chemical Product and Company Identification Pamabrom Common Name/ Trade Name Pamabrom Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds. Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various SubstancesNon-flammable in presence of shocks. Explosion Hazards in Presence Slightly explosive in presence of open flames and sparks. Non-explosive in presence of shocks. of Various Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. As with most organic solids, fire is possible at elevated temperatures Special Remarks on Fire Hazards Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust Hazardsexplosion hazard. Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Pamabrom Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Do not breathe dust. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Crystalline powder.)OdorAmine like. (Slight.) TasteNot available. Molecular Weight348.2 g/mole White. Color Not available. pH (1% soln/water) Boiling PointNot available. Melting point: 295 -316 deg. C. Melting Point Decomposition temperature: 300°C (572°F) Not available. Critical Temperature Specific GravityNot available. Not applicable. Vapor Pressure Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesNot available. SolubilitySoluble in cold water. Solubility in water: 30 g/100 ml @ 25 deg. C Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityExcess heat, incompatible materials Incompatibility with variousNot available. substances CorrosivityNot available. Pamabrom Not available. Special Remarks on Reactivity Not available. Special Remarks on Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 940 mg/kg [Rat]. Chronic Effects on Humans Not available. Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Special Remarks on Not available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherPotential Health Effects Toxic Effects on HumansSkin: May cause skin irritation. Eyes: Dust may cause eye irritation. Inhalation: Dust may cause respiratory tract irritation. Ingestion: It may cause gastrointestinal tract irritation with nausea or vomiting, and diarrhea. It is a Theophylline analog and is used as an over-the-counter diuretic. Therefore, it can affect the urinary system. Since it is a Theophylline analog, it may have similar effects as Theophylline. Theophylline may affect the cardiovascular system(cardiac arrhythmias, hypotension, pericardial pain), and behavior/Central Nervous System(headache, insomnia, dizziness, restlessness, agitation, excitement, incoordination, somnolence, coma), respiration, metabolism (metabolic acidosis, weight loss), liver, blood (changes in white blood cell count). Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are more toxic than the product itself. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Pamabrom Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Not applicable. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: No products were found. Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other ClassificationsWHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC)This product is not classified according S24/25- Avoid contact with skin and eyes. to the EU regulations. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Pamabrom Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 危险品运输编码: NONH for all modes of transport