5632-47-3

• 常用中文名：1-亚硝基哌嗪 三氟乙酸盐
• 常用英文名：1-Nitrosopiperazine
• CAS号：5632-47-3
• 分子式：C₄H₉N₃O
• 分子量：115.134
• 发布时间：2016-02-27 01:18:03
• 更新时间：2026-07-01 15:15:58

名称

• 中文名: 1-亚硝基哌嗪 三氟乙酸盐
• 英文名: N-Nitrosopiperazine
• 中文别名: 1-亚硝基哌嗪,N-亚硝基哌嗪,利福昔明中间体; 丁螺环酮亚硝基杂质; 5-((1S,4S)-2-氧杂-5-氮杂二环[2.2.1]庚烷-5-基)-N-(3-(二氟甲基)-1-((1r,4r)-4-甲酰基环己基)-1H-吡唑-4-基)吡唑并[1,5-a]嘧啶-3-甲酰胺; 1-亚硝基哌嗪; N-硝基哌嗪; 1-亚硝基哌嗪盐酸盐; N-硝基哌哌嗪; N-亚硝基哌嗪盐酸盐; N-亚硝基哌嗪; 利福昔明杂质15; 利福昔明杂质5
• 英文别名: 1-Nitrosopiperizine; 1-Nitroso-Piperazine HCl; Piperazine, 1-nitroso; Birone Nitroso Impurity; Rifaximin Impurity 15; Rifaximin imp(NP); N-NITROSOPIPERAZINE; Rifaximin Impurity 5; 1-nitrosopiperazine; N-Nitrosopiperazine in acetonitrile; 1-Nitroso-Piperazine Trifluoroacetate; N-Nitroso-Piperazine Hydrochloride; MONONITROSOPIPERAZINE; N-Nitroso Piperazine Solution; N- Nitrosopiperazine MONOMER; N-MONONITROSOPIPERAZINE

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 264.5±33.0 °C at 760 mmHg
• 分子式: C₄H₉N₃O
• 分子量: 115.134
• 闪点: 113.8±25.4 °C
• 精确质量: 115.074562
• PSA: 44.70000
• LogP: 0.18
• 蒸汽压: 0.0±0.5 mmHg at 25°C
• 折射率: 1.602

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TM2450000 CHEMICAL NAME : Piperazine, 1-nitroso- CAS REGISTRY NUMBER : 5632-47-3 BEILSTEIN REFERENCE NO. : 0112147 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C4-H9-N3-O MOLECULAR WEIGHT : 115.16 WISWESSER LINE NOTATION : T6M DNTJ DNO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2260 mg/kg TOXIC EFFECTS : Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Lungs, Thorax, or Respiration - acute pulmonary edema Liver - fatty liver degeneration TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5400 mg/kg/60W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Reproductive - Tumorigenic effects - uterine tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 720 mg/kg/20W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1400 mg/kg/60W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors Blood - tumors MUTATION DATA TYPE OF TEST : Host-mediated assay TEST SYSTEM : Rodent - mouse Bacteria - Escherichia coli DOSE/DURATION : 150 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 272,161,1992

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