10314-90-6

• 常用中文名：Oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione,1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-5-hydroxy-4b,7,7,10a,12a-pentamethyl-,(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)
• 常用英文名：Oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione,1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-5-hydroxy-4b,7,7,10a,12a-pentamethyl-,(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)
• CAS号：10314-90-6
• 分子式：C₂₆H₃₂O₆
• 分子量：440.52900
• 相关类别： 信号通路 NF-κB信号通路 KEAP1-Nrf2
• 发布时间：2017-11-24 08:29:36
• 更新时间：2026-09-01 11:37:03
• 7-Deacetylgedunin 是 Keap1/Nrf2/HO-1的激活剂。7-Deacetylgedunin 减轻 LPS 诱导的小鼠死亡。7-Deacetylgedunin 抑制了 Keap1 表达和巨噬细胞增殖。7-Deacetylgedunin 对体内外炎症均有抑制作用。

名称

• 英文名: 7-deacetylgedunin
• 英文别名: 7-Deacetilgedunin; 7-Deacetoxy-7-hydroxygedunin; Deacetylgedunin; (13α,14β,15β,17aα)-14,15:21,23-Dioxy-7α-hydroxy-4,4,8-trimethyl-D-homo-24-nor-17-oxa-5α-chola-1,20,22-triene-3,16-dione; Oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione, 1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-5-hydroxy-4b,7,7,10a,12a-pentamethyl-, (1S,3aS,4,4bS,5R,6,10,10bR,12aS); 7-Deacetylgedunin; 7-Desacetylgedunin; (13α,17aα)-14β,15β:21,23-Dioxy-7α-hydroxy-4,4,8-trimethyl-17-oxa-D-homo-24-nor-5α-chola-1,20,22-triene-3,16-dione

物化性质

• 密度: 1.29g/cm3
• 沸点: 596ºC at 760 mmHg
• 分子式: C₂₆H₃₂O₆
• 分子量: 440.52900
• 闪点: 314.2ºC
• 精确质量: 440.22000
• PSA: 89.27000
• LogP: 3.98990
• 蒸汽压: 4.75E-15mmHg at 25°C
• 折射率: 1.6

生物活性

• 描述: 7-Deacetylgedunin 是 Keap1/Nrf2/HO-1的激活剂。7-Deacetylgedunin 减轻 LPS 诱导的小鼠死亡。7-Deacetylgedunin 抑制了 Keap1 表达和巨噬细胞增殖。7-Deacetylgedunin 对体内外炎症均有抑制作用。
• 相关类别:
  信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Chen JY, et al. 7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling. Oncotarget. 2017 Jul 5;8(33):55051-55063.

合成路线

13072-74-7 ~8% 10314-90-6 10314-90-6

文献：Kehrli, Anne R. H.; Taylor, David A. H.; Niven, Margaret Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 2057 - 2065

13072-74-7 ~15% 10314-90-6 23577-81-3 23577-82-4

文献：Kehrli, Anne R. H.; Taylor, David A. H.; Niven, Margaret Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 2057 - 2065

上下游产品

上游产品  1
13072-74-7
下游产品  1
10314-91-7