91076-93-6

• 常用中文名：3-氨基-5-(4-氯苯基)噻吩-2-羧酸甲酯
• 常用英文名：Methyl 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylate
• CAS号：91076-93-6
• 分子式：C₁₂H₁₀ClNO₂S
• 分子量：267.73100
• 相关类别： 医药中间体 杂环化合物 噻吩类化合物
• 发布时间：2018-12-27 18:47:19
• 更新时间：2024-01-10 15:07:03
• 下载msds

名称

• 中文名: 3-氨基-5-(4-氯苯基)噻吩-2-甲酸甲酯
• 英文名: Methyl 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylate
• 中文别名: 3-氨基-5-(4-氯苯基)噻吩-2-羧酸甲酯
• 英文别名: MFCD00052591; Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate

物化性质

• 密度: 1.363g/cm3
• 沸点: 465.9ºC at 760mmHg
• 熔点: 140-141ºC
• 分子式: C₁₂H₁₀ClNO₂S
• 分子量: 267.73100
• 闪点: 235.5ºC
• 精确质量: 267.01200
• PSA: 80.56000
• LogP: 4.01850
• 外观性状: 白色至淡黄色晶体粉末
• 折射率: 1.633
• 储存条件: 室温，干燥

MSDS

Name: Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate 97% Material Safety Data Sheet Synonym: None Known CAS: 91076-93-6 Section 1 - Chemical Product MSDS Name:Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate 97% Material Safety Data Sheet Synonym:None Known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 91076-93-6 Methyl 3-amino-5-(4-chlorophenyl)thiop 97% unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 91076-93-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white to cream Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 141 - 143 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C12H10ClNO2S Molecular Weight: 268 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Strong oxidizing agents, acid chlorides. Hazardous Decomposition Products: Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 91076-93-6 unlisted. LD50/LC50: Not available. Carcinogenicity: Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 91076-93-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 91076-93-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 91076-93-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R20/21/22;R36/37/38
• 安全声明 (欧洲): S22-S26-S36/37/39
• 海关编码: 2934999090

合成路线

78583-86-5 2365-48-2 ~% 91076-93-6

文献：Synthesis, , # 3 p. 275 - 276

99-91-2 2365-48-2 68-12-2 ~% 91076-93-6

文献：Journal of Medicinal Chemistry, , vol. 49, # 24 p. 7095 - 7107

67-56-1 187949-86-6 ~% 91076-93-6

文献：European Journal of Medicinal Chemistry, , vol. 76, p. 343 - 351

99-91-2 ~% 91076-93-6

文献：European Journal of Medicinal Chemistry, , vol. 65, p. 223 - 231

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%