310427-94-2

• 常用中文名：ARG-GLU: EDANS-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-LYS: DABCYL-ARG
• 常用英文名：Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg trifluoroacetate salt
• CAS号：310427-94-2
• 分子式：C₉₁H₁₂₉N₂₅O₂₅S
• 分子量：2005.22
• 相关类别： 信号通路 神经信号通路 β-分泌
• 发布时间：2019-01-13 20:48:18
• 更新时间：2026-06-30 20:11:06
• RE(EDANS)EVNLDAEFK(DABCYL)R是EDANS和DABCYL双重标记的肽,用作BACE1的荧光底物(Em=360nm,Ex=528nm)。RE(EDANS)EVNLDAEFK(DABCYL)R可用于BACE1活性测量,酶活性水平与荧光反应成正比[1]。

名称

• 中文名: ARG-GLU: EDANS-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-LYS: DABCYL-ARG
• 英文名: Arg-Glu: EDANS-: Asn670,Leu671-Amyloid b/A4 Protein Precursor770: 668-675-Lys: DABCYL-Arg
• 英文别名: arg-glu(edans)-(asn670,leu671)-app770 (668-675)-lys(dabcyl)-arg; g-Glu: EDANS-: Asn670,Leu671-Amyloid b/A4 Protein Precursor770: -Lys: DABCYL-g; G-GLU(EDANS)-(ASN670,LEU671)-APP770 -LYS(DABCYL)-G; g-Glu(Edans)-(Asn670, Leu671)-Amyloidb/A4 Protei; H-G-GLU(EDANS)-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-LYS(DABCYL)-G-OH; L-ginyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-glutaminyl-L-α-glutamyl-L-valyl-L-aspaginyl-L-leucyl-L-α-asptyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]-L-lysyl-L-ginine; g-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 -Lys(DABCYL)-g; g-Glu(EDANS)-(Asn670,Leu671)-Amyloid beta/A4 Protein Precursor770 -Lys(DABCYL)-g trifluoroacetate salt; arg-glu(edans)-glu-val-asn-leu-asp-ala-glu-phe-lys(dabcyl)-arg; h-arg-glu(edans)-glu-val-asn-leu-asp-ala-glu-phe-lys(dabcyl)-arg-oh; arg-glu(edans)-[asn670,leu671]-amyloid b/a4 protein precursor 770 fragment 669-674-(dabcyl)lys-arg; G-GLU(EDANS)-(ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR770 -LYS (DABCYL)-G; β-Secretase Substrate IV, Fluorogenic; g-Glu(EDANS)-(Asn,Leu1)-Amyloid β/A4 Protein Precursor -Lys(DABCYL)-g trifluoroacetate salt; g-Glu(EDANS)-(Asn,Leu)-Amyloid β/A4 Protein Precursor -Lys(DABCYL)-g trifluoroacetate salt; g-Glu(EDANS)-[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment -(DABCYL)Lys-g; G-GLU(EDANS)-[ASN670, LEU671]-AMYLOID B/A4 PROTEIN PRECURSOR 770 FRAGMENT -(DABCYL)LYS-G; L-ginine, L-ginyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-glutaminyl-L-α-glutamyl-L-valyl-L-aspaginyl-L-leucyl-L-α-asptyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]-L-lysyl; G-GLU(EDANS)-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-LYS(DABCYL)-G

物化性质

• 分子式: C₉₁H₁₂₉N₂₅O₂₅S
• 分子量: 2005.22
• 精确质量: 2003.93000
• PSA: 823.15000
• LogP: 8.81010

生物活性

• 描述: RE(EDANS)EVNLDAEFK(DABCYL)R是EDANS和DABCYL双重标记的肽,用作BACE1的荧光底物(Em=360nm,Ex=528nm)。RE(EDANS)EVNLDAEFK(DABCYL)R可用于BACE1活性测量,酶活性水平与荧光反应成正比[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> β-分泌
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Ortega A, et.al. Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2183-7.

安全

• 安全声明 (欧洲): 22-24/25
• WGK德国: 3