529-40-8

• 常用中文名：商陆素; 3,5 ,3'-三羟基-7,4'-二甲氧基黄酮
• 常用英文名：Ombuin
• CAS号：529-40-8
• 分子式：C₁₇H₁₄O₇
• 分子量：330.289
• 相关类别： 天然产物 黄酮类化合物
• 发布时间：2018-12-28 13:26:26
• 更新时间：2024-01-08 11:13:15
• Ombuin 是从花椒中分离出的,具有广谱抗菌作用,MIC 为 125 至 500 μg/mL。

名称

• 中文名: 3,5,3'-三羟基-7,4'-二甲氧基黄酮
• 英文名: ombuin
• 英文别名: 4',7-Dimethoxy-3,3',5-trihydroxyflavone; ombuine; 3,5-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-chromen-4-one; FLAVONE,4',7-DIMETHOXY-3,3',5-TRIHYDROXY; 4',7-dimethylquercetin; 4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-; 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxychromen-4-one; quercetin 7,4'-dimethyl ether; Flavone, 4',7-dimethoxy-3,3',5-trihydroxy-; Ombuin; 7,4'-Di-O-methylquercetin; 3,5,3'-trihydroxy-7,4'-dimethoxyflavone

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 593.7±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄O₇
• 分子量: 330.289
• 闪点: 222.1±23.6 °C
• 精确质量: 330.073944
• PSA: 109.36000
• LogP: 2.92
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.681
• 储存条件: 2-8℃，密封，干燥

生物活性

• 描述: Ombuin 是从花椒中分离出的,具有广谱抗菌作用,MIC 为 125 至 500 μg/mL。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Nooreen Z, et al. Characterization and evaluation of bioactive polyphenolic constituents from Zanthoxylum armatum DC., a traditionally used plant. Biomed Pharmacother. 2017 May;89:366-375.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LK8332000 CHEMICAL NAME : Flavone, 4',7-dimethoxy-3,3',5-trihydroxy- CAS REGISTRY NUMBER : 529-40-8 BEILSTEIN REFERENCE NO. : 0338215 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C17-H14-O7 MOLECULAR WEIGHT : 330.31 WISWESSER LINE NOTATION : T66 BOEVJ CR CQ DO1& DQ GQ IO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 166 nmol/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,297,1978

安全

• 海关编码: 2914509090

合成路线

117-39-5 74-88-4 ~28% 529-40-8 572-32-7

文献：Shi, Zhi-Hao; Li, Nian-Guang; Tang, Yu-Ping; Wei-Li; Lian-Yin; Yang, Jian-Ping; Hao-Tang; Duan, Jin-Ao European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 210 - 222

77-78-1 153-18-4 ~% 603-61-2 529-40-8 详细

文献：Yamauchi, Kosei; Mitsunaga, Tohru; Inagaki, Mizuho; Suzuki, Tohru Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 13 p. 3331 - 3340

117-39-5 77-78-1 ~% 529-40-8

文献：Chand, Lal; Maurya, R.; Ray, A. B. Journal of the Indian Chemical Society, 1982 , vol. 59, # 8 p. 1001 - 1003

186581-53-3 117-39-5 ~15% 529-40-8 2068-02-2 详细

文献：Matsuda, Hisashi; Morikawa, Toshio; Toguchida, Iwao; Yoshikawa, Masayuki Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 6 p. 788 - 795

20188-85-6 ~% 492-61-5 6014-42-2 529-40-8

文献：Inigo, Raul P. A.; Pomilio, Alicia B. Phytochemistry (Elsevier), 1985 , vol. 24, # 2 p. 347 - 350

1832-98-0 ~% 529-40-8

文献：Narasimhachari et al. Proceedings - Indian Academy of Sciences, Section A, 1953 , # 37 p. 104,112

60444-56-6 ~% 529-40-8

文献：Deulofeu; Schopflocher Gazzetta Chimica Italiana, 1953 , vol. 83, p. 449,454 Anales de la Asociacion Quimica Argentina (1921-2001), 1956 , vol. 44, p. 34,39

90798-12-2 ~% 529-40-8

文献：Deulofeu; Schopflocher Gazzetta Chimica Italiana, 1953 , vol. 83, p. 449,454 Anales de la Asociacion Quimica Argentina (1921-2001), 1956 , vol. 44, p. 34,39

21736-96-9 ~% 529-40-8

文献：Natoli, Mariapina; Nicolosi, Giovanni; Piattelli, Mario Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5776 - 5778

上下游产品

上游产品  8
117-39-5 74-88-4 77-78-1 153-18-4
186581-53-3 20188-85-6 60444-56-6 90798-12-2
下游产品  1
1245-15-4

海关

海关编码	2914509090
中文概述	2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙酮报明包装
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%