1828-66-6

• 常用中文名：4-吗啉磺酰氯
• 常用英文名：4-Morpholinesulfonyl chloride
• CAS号：1828-66-6
• 分子式：C₄H₈ClNO₃S
• 分子量：185.629
• 相关类别： 有机原料 羧酸类化合物及衍生物 羧酸酰卤化物
• 发布时间：2018-03-04 08:00:00
• 更新时间：2024-01-06 01:38:01
• 下载msds

名称

• 中文名: 吗啉-4-磺酰氯
• 英文名: morpholine-4-sulfonyl chloride
• 中文别名: 4-吗啉磺酰氯; 吗啉磺酰氯; 4-吗啉磺酰氯
• 英文别名: 4-Morpholinesulfonyl chloride; morpholinosulphonyl chloride; N-morpholinesulfonyl chloride; 4-morpholinesulphonyl chloride; morpholine-N-sulfonyl chloride; N-chlorosulphonyl morpholine; N-chlorosulfonylmorpholine; chloromorpholin-4-ylsulfone; morpholine-4-sulfonyl chloride

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 299.7±29.0 °C at 760 mmHg
• 分子式: C₄H₈ClNO₃S
• 分子量: 185.629
• 闪点: 135.1±24.3 °C
• 精确质量: 184.991348
• PSA: 54.99000
• LogP: -0.76
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.538
• 储存条件: 2-8°C

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Morpholine-4-sulfonyl chloride Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. H318:Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing Section3. Composition/information on ingredients. Ingredient name:Morpholine-4-sulfonyl chloride CAS number:1828-66-6 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels, refrigerated. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula: C4H8ClNO3S Molecular weight: 185.6 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, sulfur oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information UN Number:UN3265 Class: 8 Packing group: III Proper shipping name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (Morpholine-4-sulfonyl chloride) Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26
• 海关编码: 2934999090

合成路线

110-91-8 ~99% 1828-66-6

文献：GILEAD SCIENCES, INC.; CAI, Zhenhong, R.; CHEN, Xiaowu; FARDIS, Maria; JABRI, Salman, Y.; JIN, Haolun; KIM, Choung, U.; METOBO, Sanuel, E.; MISH, Michael, R.; PASTOR, Richard, M. Patent: WO2005/117904 A2, 2005 ; Location in patent: Page/Page column 463-464 ;

108085-16-1 ~% 1828-66-6

文献：WO2006/77414 A1, ; Page/Page column 170-171 ; WO 2006/077414 A1

110-91-8 7791-25-5 ~99% 1828-66-6

文献：Gilead Sciences, Inc. Patent: WO2004/35576 A2, 2004 ; Location in patent: Page 227 ;

10024-89-2 ~83% 1828-66-6

文献：Chatterjee, Sankar; Ator, Mark A.; Bozyczko-Coyne, Donna; Josef, Kurt; Wells, Gregory; Tripathy, Rabindranath; Iqbal, Mohamed; Bihovsky, Ron; Senadhi, Shobha E.; Mallya, Satish; O'Kane, Teresa M.; McKenna, Beth Ann; Siman, Robert; Mallamo, John P. Journal of Medicinal Chemistry, 1997 , vol. 40, # 23 p. 3820 - 3828

23328-69-0 ~% 1828-66-6

文献：Justus Liebigs Annalen der Chemie, , vol. 624, p. 25,29

15159-40-7 ~% 1828-66-6

文献：DE946710 , ;

上下游产品

上游产品  6
110-91-8 108085-16-1 7791-25-5 10024-89-2
23328-69-0 15159-40-7
下游产品  0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%