1828-66-6

1828-66-6 structure

Name: 4-Morpholinesulfonyl chloride
Chemical Name: morpholine-4-sulfonyl chloride
CAS Number: 1828-66-6
Molecular Formula: C₄H₈ClNO₃S
Molecular Weight: 185.629
Catalog: Organic raw materials Carboxylic compounds and derivatives Carboxylic acid halide
Create Date: 2018-03-04 08:00:00
Modify Date: 2024-01-06 01:38:01

Name	morpholine-4-sulfonyl chloride
Synonyms	4-Morpholinesulfonyl chloride morpholinosulphonyl chloride N-morpholinesulfonyl chloride 4-morpholinesulphonyl chloride morpholine-N-sulfonyl chloride N-chlorosulphonyl morpholine N-chlorosulfonylmorpholine chloromorpholin-4-ylsulfone morpholine-4-sulfonyl chloride

Density	1.5±0.1 g/cm3
Boiling Point	299.7±29.0 °C at 760 mmHg
Molecular Formula	C₄H₈ClNO₃S
Molecular Weight	185.629
Flash Point	135.1±24.3 °C
Exact Mass	184.991348
PSA	54.99000
LogP	-0.76
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.538
Storage condition	2-8°C

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: Morpholine-4-sulfonyl chloride
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

H318:Causes serious eye damage
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

Section3. Composition/information on ingredients.
Ingredient name:Morpholine-4-sulfonyl chloride
CAS number:1828-66-6

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels, refrigerated.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula: C4H8ClNO3S
Molecular weight: 185.6

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, sulfur oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
UN Number:UN3265 Class: 8 Packing group: III
Proper shipping name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (Morpholine-4-sulfonyl chloride)

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26
HS Code	2934999090

110-91-8

~99%

1828-66-6

Literature: GILEAD SCIENCES, INC.; CAI, Zhenhong, R.; CHEN, Xiaowu; FARDIS, Maria; JABRI, Salman, Y.; JIN, Haolun; KIM, Choung, U.; METOBO, Sanuel, E.; MISH, Michael, R.; PASTOR, Richard, M. Patent: WO2005/117904 A2, 2005 ; Location in patent: Page/Page column 463-464 ;