135575-42-7

• 常用中文名：纽莫康定 B0
• 常用英文名：Pneumocandin B0
• CAS号：135575-42-7
• 分子式：C₅₀H₈₀N₈O₁₇
• 分子量：1065.214
• 相关类别： 信号通路 抗感染 真菌
• 发布时间：2018-08-23 23:28:46
• 更新时间：2024-01-02 08:14:14
• Pneumocandin B0(L-688786)是Cancidas的合成中间体。

名称

• 中文名: 纽莫康定 B0
• 英文名: Pneumocandin B0
• 中文别名: 纽莫康定; 纽莫康定B0(肺囊康定); 纽莫康定B0((肺囊康定)
• 英文别名: N-{(2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-20-[(1R)-3-Amino-1-hydroxy-3-oxopropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide; 1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosine-20-propanamide, 23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-9-[(10,12-dimethyl-1-oxotetradecyl)amino]tetracosahydro-β,2,11,12,15-pentahydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxo-, (βR,2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-; PneumocandinB0; 1H-Dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosine-20-propanamide, 23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-9-[(10,12-dimethyl-1-oxotetradecyl)amino]tetracosahydro-β,2,11 ,12,15-pentahydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxo-, (βR,2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-; B0 PneuMocandin B0; pneumocandin Bo; Pneumocardin B0

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 1442.9±65.0 °C at 760 mmHg
• 分子式: C₅₀H₈₀N₈O₁₇
• 分子量: 1065.214
• 闪点: 826.5±34.3 °C
• 精确质量: 1064.564087
• PSA: 411.28000
• LogP: -5.00
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.630
• 储存条件: -20°C

生物活性

• 描述: Pneumocandin B0(L-688786)是Cancidas的合成中间体。
• 相关类别:
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 感染
• 参考文献:

  [1]. Welch CJ, et al. Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0. J Chromatogr A. 2006 Jan 6;1101(1-2):204-13.

  [2]. Leonard WR Jr, et al. Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0. J Org Chem. 2007 Mar 30;72(7):2335-43.