804-30-8

• 常用中文名：呋喃硫胺
• 常用英文名：Fursultiamine
• CAS号：804-30-8
• 分子式：C₁₇H₂₆N₄O₃S₂
• 分子量：398.543
• 相关类别： 原料药 维生素类与矿物质类药 维生素B类药
• 发布时间：2018-07-21 00:08:13
• 更新时间：2026-07-01 19:47:45
• Fursultiamine 是一种维生素 B1 衍生物。

名称

• 中文名: 呋喃硫胺
• 英文名: N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(oxolan-2-ylmethyldisulfanyl)pent-2-en-2-yl]formamide
• 中文别名: N-((4-氨基-2-甲基嘧啶-5-基)甲基)-N-(5-羟基-3-(((四氢呋喃-2-基)甲基)二硫烷基)戊-2-烯-2-基)甲酰胺; 长效维生素B1; 呋喃硫铵; N-[(4-氨基-2-甲基-5-嘧啶基)-甲基]-N-{4-羟基-1-甲基-2-[(四氢呋喃甲基)二硫]-1-丁烯基}甲酰胺; N-(4氨基-2-甲基-5-嘧啶甲基)-N-(4羟基-1-甲基-2-四氢呋喃甲基二硫-1-丁烯基)甲酰胺; 呋喃硫胺,10 MM DMSO 溶液; 盐酸呋喃硫铵
• 英文别名: n-(4-amino-2-methylpyrimidin-5-ylmethyl)-n-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamide; Linamin; Furan thiamine; N-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(oxolan-2-ylmethyldisulfanyl)pent-2-en-2-yl]formamide; thiaminetetrahydrofurfuryldisulfide; Fursultiamine, 10 mM in DMSO; ttfd; Fursultiamine Hydrochloride RS; Thiamine tetrahydrofurfuryl disulfide; Thiamin tetrahydrofurfuryl disulfide; THIAMINE TETRAHYDROFURFURYL DISULFIDE (TTFD); EINECS 212-357-1; Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]- (6CI, 8CI); TTFD; Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]; Adventan; Diteftin; FURSULTIAMINE; Judolor; N-(-4-amino-2-methyl-5-pyrimidinylmethyl)-N-(-4-hydroxyl-1-methyl-2-tetrahycofurfury(dithio-1-bute; Fursultiamine //BP; diteftin; Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]; ret-b(sub1); alinaminf; Tetrahydrofurfuryl thiamine disulfide; RetB1; Fursutiamine; N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-{5-hydroxy-3-[(tetrahydro-2-furanylmethyl)disulfanyl]-2-penten-2-yl}formamide; N-((4-Amino-2-methylpyrimidin-5-yl)methyl)-N-(5-hydroxy-3-(((tetrahydrofuran-2-yl)methyl)disulfanyl)pent-2-en-2-yl)formamide; judolor; n-(4-amino-2-methylpyrimidin-5-ylmethyl)-n-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamid; Fursultiamine HCL JP //BP; thiamine tetrahdydrofufuryl disulfide; Fursultiamine (base and/or unspecified salts); FURSULTIAMINE HYDROCHLORIDE; fursultiamin; Derivative Fursultiamine; N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]formamide; Alinamin F; adventan; linamin; ((tetrahydrofurfuryl)dithio)-1-butenyl); MFCD00867383; Fursultiamine Base; Retar B1; Fursultiamin; Fursultiamine###Fursultiamine Hcl; N-(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]forma; Thiamin-tetrahydrofurfuryl-disulfid; Fursultiaminlim; Alinaxin; N-[(2-Methyl-4-amino-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydrofuran-2-yl)methyl]dithio]-1-butenyl]formamide; Alion F

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 652.3±55.0 °C at 760 mmHg
• 熔点: 130-136ºC (decompos.)
• 分子式: C₁₇H₂₆N₄O₃S₂
• 分子量: 398.543
• 闪点: 348.3±31.5 °C
• 精确质量: 398.144623
• PSA: 152.17000
• LogP: 2.35
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.626
• 储存条件: 2-8℃

生物活性

• 描述: Fursultiamine 是一种维生素 B1 衍生物。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kobayashi T, et al. Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis. Inflamm Res. 2005 Jun;54(6):249-55.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LQ0750000 CHEMICAL NAME : Formamide, N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydro xy-1-methyl-2- ((tetrahydrofurfuryl)dithio)-1-butenyl)- CAS REGISTRY NUMBER : 804-30-8 BEILSTEIN REFERENCE NO. : 0052964 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C17-H26-N4-O3-S2 MOLECULAR WEIGHT : 398.59 WISWESSER LINE NOTATION : T6N CNJ B1 DZ E1NVHY1&UY2QSS1- BT5OTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3016380 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3016380 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,699,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 30,242,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 430 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,699,1982