1013937-63-7

1013937-63-7结构式

常用中文名：VTP-27999 2,2,2-三氟乙酸盐
常用英文名：VTP 27999 trifluoroacetate
CAS号：1013937-63-7
分子式：C₂₈H₄₂ClF₃N₄O₇
分子量：639.10400
相关类别：信号通路代谢酶/蛋白酶肾素
发布时间：2019-01-01 18:35:59
更新时间：2026-06-30 16:20:40
VTP-27999是烷基胺肾素抑制剂。

化源商城直购

中文名	N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯,2,2,2-三氟乙酸盐
英文名	methyl N-[2-[(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate,2,2,2-trifluoroacetic acid
中文别名	N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四 (2-((R)-(3-氯苯基)((R)-1-(((S)-2-(甲基氨基)-3-((R)-四氢-2H-吡喃-3-基)丙基)氨基甲酰基)哌啶-3-基)甲氧基)乙基)氨基甲酸甲酯 2,2,2-三氟乙酸盐 N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]-2,2,2-三氟乙酸氨基甲酸甲酯 N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯 2,2,2-三氟乙酸盐 VTP 27999 三氟乙酸盐
英文别名	inhibit,VTP27999 TFA,Renin,VTP-27999,VTP 27999 TFA,VTP 27999,Inhibitor,VTP VTP-27999 2,2,2-trifluoroacetate (VTP 27999, 2,2,2-trifluoroacetate 2-trifluoroacetate VTP-27999 2,2,2-trifluoroacetate VTP-27999, (2,2,2-trifluoroacetate) (1:1) methyl N-[2-[(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]cbamoyl]piperidin-3-yl]methoxy]ethyl]cbamate,2,2,2-trifluoroacetic acid Methyl (2-((R)-(3-chlorophenyl)((R)-1-(((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propyl)cbamoyl)piperidin-3-yl)methoxy)ethyl)cbamate 2,2,2-trifluoroacetate Methyl N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]cbamate trifluoroacetate VTP 27999; 2;2;2-TRIFLUOROACETATE;VTP27999; 2;2;2-TRIFLUOROACETATE;VTP-27999 VTP-27999 TFA methyl {2-[((R)-(3-chlorophenyl){(3R)-1-[({(2S)-2-(methyl-amino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]-3-piperidinyl}methyl)oxy]ethyl}carbamate trifluoroacetate N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]cbamic acid methyl ester 2,2,2-trifluoroacetate CBAMIC ACID, N-[2-[(R)-(3-CHLOROPHENYL)[(3R)-1-[[[(2S)-2-(METHYLAMINO)-3-[(3R)-TETRAHYDRO-2H-PYRAN-3-YL]PROPYL]AMINO]carbonyl]-3-PIPERIDINYL]METHOXY]ETHYL]-, METHYL ESTER, 2,2,2-TRIFLUOROACETATE (1:1) VTP-27999 (2,2,2-trifluoroacetate) methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate trifluoroacetate CS-0312 VTP-27999 Trifluoroacetate VTP-27999 (trifluoroacetate salt)

描述	VTP-27999是烷基胺肾素抑制剂。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 肾素研究领域 >> 心血管疾病
参考文献	[1]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082. [2]. Lanqi Jia? et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751 [3]. Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25.

分子式	C₂₈H₄₂ClF₃N₄O₇
分子量	639.10400
精确质量	638.26900
PSA	138.46000
LogP	5.32390
储存条件	-20°C，密闭，干燥

942142-74-7

1013937-63-7

文献：Jia, Lanqi; Simpson, Robert D.; Yuan, Jing; Xu, Zhenrong; Zhao, Wei; Cacatian, Salvacion; Tice, Colin M.; Guo, Joan; Ishchenko, Alexey; Singh, Suresh B.; Wu, Zhongren; McKeever, Brian M.; Bukhtiyarov, Yuri; Johnson, Judith A.; Doe, Christopher P.; Harrison, Richard K.; McGeehan, Gerard M.; Dillard, Lawrence W.; Baldwin, John J.; Claremon, David A. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 747 - 751