1013937-63-7

1013937-63-7 structure

Name: VTP 27999 trifluoroacetate
Chemical Name: methyl N-[2-[(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate,2,2,2-trifluoroacetic acid
CAS Number: 1013937-63-7
Molecular Formula: C₂₈H₄₂ClF₃N₄O₇
Molecular Weight: 639.10400
Catalog: Signaling Pathways Metabolic Enzyme/Protease Renin
Create Date: 2019-01-01 18:35:59
Modify Date: 2024-01-02 14:33:27
VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin

Name	methyl N-[2-[(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate,2,2,2-trifluoroacetic acid
Synonyms	methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate trifluoroacetate CS-0312 methyl {2-[((R)-(3-chlorophenyl){(3R)-1-[({(2S)-2-(methyl-amino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]-3-piperidinyl}methyl)oxy]ethyl}carbamate trifluoroacetate VTP-27999 (2,2,2-trifluoroacetate)

Description	VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Renin Research Areas >> Cardiovascular Disease
References	[1]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082. [2]. Lanqi Jia? et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751 [3]. Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25.

Molecular Formula	C₂₈H₄₂ClF₃N₄O₇
Molecular Weight	639.10400
Exact Mass	638.26900
PSA	138.46000
LogP	5.32390

942142-74-7

1013937-63-7

Literature: Jia, Lanqi; Simpson, Robert D.; Yuan, Jing; Xu, Zhenrong; Zhao, Wei; Cacatian, Salvacion; Tice, Colin M.; Guo, Joan; Ishchenko, Alexey; Singh, Suresh B.; Wu, Zhongren; McKeever, Brian M.; Bukhtiyarov, Yuri; Johnson, Judith A.; Doe, Christopher P.; Harrison, Richard K.; McGeehan, Gerard M.; Dillard, Lawrence W.; Baldwin, John J.; Claremon, David A. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 747 - 751