61325-80-2

• 常用中文名：氟甲氮平
• 常用英文名：Flumezapine
• CAS号：61325-80-2
• 分子式：C₁₇H₁₉FN₄S
• 分子量：330.42300
• 发布时间：2018-08-28 00:43:10
• 更新时间：2024-01-05 22:05:34

名称

• 中文名: 氟甲氮平
• 英文名: 7-fluoro-2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
• 英文别名: Flumezapinum [INN-Latin]; Flumezapine (USAN); Flumezapinum; 10H-Thieno(2,3-b)(1,5)benzodiazepine,7-fluoro-2-methyl-4-(4-methyl-1-piperazinyl); Flumezapina [INN-Spanish]; 7-fluoro-2-methyl-4-(4-methyl-piperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine; Flumezapina; FLUMEZAPINE; 7-Fluoro-2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine

物化性质

• 密度: 1.383g/cm3
• 沸点: 479.498ºC at 760 mmHg
• 分子式: C₁₇H₁₉FN₄S
• 分子量: 330.42300
• 闪点: 243.792ºC
• 精确质量: 330.13100
• PSA: 59.11000
• LogP: 3.02770
• 折射率: 1.697

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XJ9007100 CHEMICAL NAME : 10H-Thieno(2,3-b)(1,5)benzodiazepine, 7-fluoro-2-methyl-4-(4-methyl-1-piperazinyl)- CAS REGISTRY NUMBER : 61325-80-2 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C17-H19-F-N4-S MOLECULAR WEIGHT : 330.46 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - body temperature decrease REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,878,1980

合成路线

109-01-3 61325-55-1 ~35% 61325-80-2

文献：Chakrabarti, Jiban K.; Horsman, Linda; Hotten, Terrence M.; Pullar, Ian A.; Tupper, David E. Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 878 - 884

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