54022-49-0

• 常用中文名：N-甲酰基神经氨酸(长春新碱杂质G)
• 常用英文名：Vinformide
• CAS号：54022-49-0
• 分子式：C₄₆H₅₄N₄O₁₀
• 分子量：822.94200
• 发布时间：2017-09-21 00:19:21
• 更新时间：2026-07-25 13:14:02
• Vinformide is a potent cytostatic agent.

名称

• 中文名: N-甲酰基神经氨酸(长春新碱杂质G)
• 英文名: N-Formyl Leurosine
• 中文别名: N-甲酰亮氨酸; 长春新碱杂质G; 硫酸长春新碱杂质G; 长春新碱杂质1; 硫酸长春新碱杂质7(长春新碱杂质G); N-甲酰环长春碱; N-甲酰白诺生
• 英文别名: Leuroformine; (1aS,3S,11S,13S,13-methyl 11-((3,3a1R,4R,5S,5,10bR)-4-acetoxy-3a-ethyl-6-formyl-5-hydroxy-8-methoxy-5-(methoxycbonyl)-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]cbazol-9-yl)-1a-ethyl-2,4,5,10,11,12,13,13a-octahydro-1aH-3,13-methanooxireno[2',3':9,10]azacycloundecino[5,4-b]indole-11-cboxylate; N-Formyl N-demethylleurosine; Vincristine Impurity 7(Vincristine Impurity G); Vincristine Impurity 1; (3′α,4′α)-4′-Deoxy-3′,4′-oxy-22-oxovincaleukoblastine; Formyl-leurosine; N-Demethyl-N-formylleurosine; N-Formyl Leurosine (Vincristine Impurity G); NS269419; N-Formyl Leurosine (Vincristine; F-Leurosine; (1aS,3S,11S,13S,13-methyl 11-((3,3a1R,4R,5S,5,10bR)-4-acetoxy-3a-ethyl-6-formyl-5-hydroxy-8-methoxy-5-(methoxycbonyl)-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]cbazol-9-yl)-1a-e; 22-Oxoleurosine; (3'a,4'a)-4'-Deoxy-3',4'-oxy-22-oxovincaleukoblastine; Vincristine Impurity G; methyl(3,4R,5S,5,10bR,13-4-(acetyloxy)-3a-ethyl-9-[(1aS,11S,13S,13-1a-ethyl-11-(methoxycbonyl)-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methano-oxireno[9,10]azacycloundecino[5,4-b]indol-11-yl]-6-formyl-5-hydroxy-8-methoxy-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]cbazole-5-cboxylate(formylleurosine); Vincaleukoblastine, 4'-deoxy-3',4'-oxy-22-oxo-, (3'α,4'α)

物化性质

• 密度: 1.42g/cm3
• 熔点: 200-210ºC
• 分子式: C₄₆H₅₄N₄O₁₀
• 分子量: 822.94200
• 精确质量: 822.38400
• PSA: 163.47000
• LogP: 4.11060
• 折射率: 1.684

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LR2962000 CHEMICAL NAME : Formyl-leurosine CAS REGISTRY NUMBER : 54022-49-0 LAST UPDATED : 198910 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C46-H54-N4-O10 MOLECULAR WEIGHT : 823.04 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Ascites tumor DOSE/DURATION : 10 mg/kg REFERENCE : EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 19,1113,1983

合成路线

23360-92-1 ~% 54022-49-0

文献：Kutney; Balsevich; Honda; et al. Canadian Journal of Chemistry, 1978 , vol. 56, # 19 p. 2560 - 2566

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