23360-92-1

• 常用中文名：长春罗新
• 常用英文名：vinleurosine
• CAS号：23360-92-1
• 分子式：C₄₆H₅₆N₄O₉
• 分子量：808.96
• 发布时间：2018-09-17 15:32:12
• 更新时间：2026-07-16 10:14:03
• 文乐菌素是一种吲哚生物碱,具有抗肿瘤活性[1]。

名称

• 中文名: 长春素
• 英文名: leurosine
• 中文别名: 长春新碱杂质-F; 长春素Leurosine; 长春新碱杂质F( 长春瑞滨杂质E); 硫酸长春新碱杂质F; 长春瑞宾杂质5(长春瑞宾杂质E); 环长春碱; 环氧长春碱; 白诺生; 酒石酸长春瑞滨杂质E; 长春新碱杂质F(亮氨酸); 硫酸长春新碱杂质6(长春新碱杂质F); 长春新碱杂质F; 长春瑞滨杂质E; 长春瑞宾杂质E; 环氧长春碱,长春素
• 英文别名: Vincristine Impurity F (Leurosine); Vinorelbine Impurity E/Leurosine/4b-Acetoxy-3,4oxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester; Vincristine Impurity F(Vinorelbine Impurity E); amotin; Vincaleukoblastine, 4'-deoxy-3',4'-oxy-, (3'α,4'α); Vincaleukoblastine,4'-deoxy-3',4'-oxy-, (3'a,4'a); (2'β,4'α,5'α)-O',5'-Cyclovincaleukoblastine; 4’-deoxy-3’,4’-oxy-,(3’-alpha,4’-alpha)-vincaleukoblastin; Vinleurosine; (3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine; (1aS,11S,13S,13-methyl 11-((3,3a1R,4R,5S,5,10bR)-4-acetoxy-3a-ethyl-5-hydroxy-8-methoxy-5-(methoxycbonyl)-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]cbazol-9-yl)-1a-ethyl-2,4,5,10,11,12,13,13a-octahydro-1aH-3,13-methanooxireno[2',3':9,10]azacycloundecino[5,4-b]indole-11-cboxylate; 4′-deoxy-3′α,4′α-oxyvincaleukoblastine(leurosine); 4b-Acetoxy-3,4oxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester; LEUROSINE; methyl(3,4R,5S,5,10bR,13-4-(acetyloxy)-3a-ethyl-9-[(1aS,11S,13S,13-1a-ethyl-11-(methoxycbonyl)-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methano-oxireno[9,10]azacycloundecino[5,4-b]indol-11-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]cbazole-5-cboxylate(leurosine); (1aS,11S,13S,13-methyl 11-((3,3a1R,4R,5S,5,10bR)-4-acetoxy-3a-ethyl-5-hydroxy-8-methoxy-5-(methoxycbonyl)-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]cbazol-9-yl)-1a-ethyl; nsc-528004; Vincristine Impurity 6(Vincristine Impurity F); 4’-deoxy-3’,4’-oxy-,(3’alpha,4’alpha)-vincaleukoblastin; 4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester; (3'alpha,4'alpha)-4'-Deoxy-3',4'-oxyvincaleukoblastine; (2'β,3'β)-O',3'-Cyclovincaleukoblastine; 4'-Deoxy-3',4'-epoxyvincaleucoblastine,9CI; Vincristine Impurity F; 4'-Deoxy-3',4'-oxyvincaleucoblastine, 9CI

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₄₆H₅₆N₄O₉
• 分子量: 808.96
• 精确质量: 808.404724
• PSA: 146.40000
• LogP: 4.08
• 折射率: 1.678
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:12

  4.可旋转化学键数量:10

  5.互变异构体数量:无

  6.拓扑分子极性表面积:146

  7.重原子数量:59

  8.表面电荷:0

  9.复杂度:1750

  10.同位素原子数量:0

  11.确定原子立构中心数量:10

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: 文乐菌素是一种吲哚生物碱,具有抗肿瘤活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. W A Creasey, et al. Biochemical effects of the Vinca alkaloids. IV. Studies with vinleurosine. Biochem Pharmacol. 1969 Jan;18(1):227-32.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OH6370000 CHEMICAL NAME : Leurosine CAS REGISTRY NUMBER : 23360-92-1 BEILSTEIN REFERENCE NO. : 0079636 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C46-H56-N4-O9 MOLECULAR WEIGHT : 809.06 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15200 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 12 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting REFERENCE : EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 mg/kg/30D-I TOXIC EFFECTS : Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death REFERENCE : EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 30 mg/kg/15D-I TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Blood - changes in leukocyte (WBC) count Related to Chronic Data - death REFERENCE : EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987

安全

• 危险品运输编码: UN 1544
• 包装等级: II
• 危险类别: 6.1(a)

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