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54022-49-0

54022-49-0 structure

54022-49-0 structure

Name: Vinformide
Chemical Name: N-Formyl Leurosine
CAS Number: 54022-49-0
Molecular Formula: C₄₆H₅₄N₄O₁₀
Molecular Weight: 822.94200
Create Date: 2017-09-21 00:19:21
Modify Date: 2026-07-25 13:14:02
Vinformide is a potent cytostatic agent.

Name	N-Formyl Leurosine
Synonyms	Leuroformine (1aS,3S,11S,13S,13-methyl 11-((3,3a1R,4R,5S,5,10bR)-4-acetoxy-3a-ethyl-6-formyl-5-hydroxy-8-methoxy-5-(methoxycbonyl)-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]cbazol-9-yl)-1a-ethyl-2,4,5,10,11,12,13,13a-octahydro-1aH-3,13-methanooxireno[2',3':9,10]azacycloundecino[5,4-b]indole-11-cboxylate N-Formyl N-demethylleurosine Vincristine Impurity 7(Vincristine Impurity G) Vincristine Impurity 1 (3′α,4′α)-4′-Deoxy-3′,4′-oxy-22-oxovincaleukoblastine Formyl-leurosine N-Demethyl-N-formylleurosine N-Formyl Leurosine (Vincristine Impurity G) NS269419 N-Formyl Leurosine (Vincristine F-Leurosine (1aS,3S,11S,13S,13-methyl 11-((3,3a1R,4R,5S,5,10bR)-4-acetoxy-3a-ethyl-6-formyl-5-hydroxy-8-methoxy-5-(methoxycbonyl)-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]cbazol-9-yl)-1a-e 22-Oxoleurosine (3'a,4'a)-4'-Deoxy-3',4'-oxy-22-oxovincaleukoblastine Vincristine Impurity G methyl(3,4R,5S,5,10bR,13-4-(acetyloxy)-3a-ethyl-9-[(1aS,11S,13S,13-1a-ethyl-11-(methoxycbonyl)-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methano-oxireno[9,10]azacycloundecino[5,4-b]indol-11-yl]-6-formyl-5-hydroxy-8-methoxy-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]cbazole-5-cboxylate(formylleurosine) Vincaleukoblastine, 4'-deoxy-3',4'-oxy-22-oxo-, (3'α,4'α)

Density	1.42g/cm3
Melting Point	200-210ºC
Molecular Formula	C₄₆H₅₄N₄O₁₀
Molecular Weight	822.94200
Exact Mass	822.38400
PSA	163.47000
LogP	4.11060
Index of Refraction	1.684

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LR2962000

CHEMICAL NAME :: Formyl-leurosine

CAS REGISTRY NUMBER :: 54022-49-0

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C46-H54-N4-O10

MOLECULAR WEIGHT :: 823.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 10 mg/kg

REFERENCE :: EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 19,1113,1983

23360-92-1 structure

23360-92-1

~%

54022-49-0 structure

54022-49-0

Literature: Kutney; Balsevich; Honda; et al. Canadian Journal of Chemistry, 1978 , vol. 56, # 19 p. 2560 - 2566

Precursor 1
23360-92-1
DownStream 0

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