65184-10-3

• 常用中文名：茶丙洛尔
• 常用英文名：Teoprolol
• CAS号：65184-10-3
• 分子式：C₂₃H₃₀N₆O₄
• 分子量：454.52200
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 肾上腺素能受体
• 发布时间：2018-07-02 14:25:36
• 更新时间：2024-01-05 20:09:04
• Teoprolol 是一种 β-adrenergic 受体阻滞剂。

名称

• 中文名: 茶丙洛尔
• 英文名: 7-[3-[[2-hydroxy-3-[(2-methyl-1H-indol-4-yl)oxy]propyl]amino]butyl]-1,3-dimethylpurine-2,6-dione
• 英文别名: Teoprololum [INN-Latin]; Teoprolol; 1H-Purine-2,6-dione,3,7-dihydro-7-(3-((2-hydroxy-3-((2-methyl-1H-indol-4-yl)oxy)propyl)amino)butyl)-1,3-dimethyl; EINECS 265-600-9; 7-{3-[2-hydroxy-3-(2-methyl-indol-4-yloxy)-propylamino]-butyl}-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; 7-(3-((2-Hydroxy-3-((2-methylindol-4-yl)oxy)propyl)amino)butyl)theophylline; D-13,312; Teoprololum

物化性质

• 密度: 1.37g/cm3
• 沸点: 747.6ºC at 760 mmHg
• 分子式: C₂₃H₃₀N₆O₄
• 分子量: 454.52200
• 闪点: 405.9ºC
• 精确质量: 454.23300
• PSA: 119.10000
• LogP: 1.42240
• 折射率: 1.665
• 储存条件: 2-8℃

生物活性

• 描述: Teoprolol 是一种 β-adrenergic 受体阻滞剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 其他
• 参考文献:

  [1]. S. D. Yuzhakov, et al. Structure-activity relationships in β-adrenoblockers. Pharmaceutical Chemistry Journal. May 1991, Volume 25, Issue 5, pp 283-295

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UO8437700 CHEMICAL NAME : 1H-Purine-2,6-dione, 3,7-dihydro-7-(3-((2-hydroxy-3-((2-methyl-1H-indol-4- yl)oxy)propyl) amino)butyl)-1,3-dimethyl- CAS REGISTRY NUMBER : 65184-10-3 BEILSTEIN REFERENCE NO. : 1234202 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C23-H30-N6-O4 MOLECULAR WEIGHT : 454.59 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1870 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 39 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 38 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982