113-80-4

• 常用中文名：[Arg8]-催产加压素
• 常用英文名：(Arg8)-Vasotocin acetate salt
• CAS号：113-80-4
• 分子式：C₄₃H₆₇N₁₅O₁₂S₂
• 分子量：1050.215
• 相关类别： 生物化工 多肽
• 发布时间：2018-09-04 21:07:10
• 更新时间：2024-01-05 16:45:03
• [Arg8]-Vasotocin是加压素/催产素激素家族的脊椎动物神经垂体肽。

名称

• 中文名: 精氨缩宫素
• 英文名: vasotocin
• 英文别名: L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginylglycinamide Cyclic (1®6)-Disulfide; 8-argininevasotocin; 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide; arginine-vasopressin; 8-Arg-vasotocin; CYS-TYR-ILE-GLN-ASN-CYS-PRO-ARG-GLY-NH2; 8-Arginine vasotocin; argiprestocin; glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-arginyl-; [ARG8]-VASOTOCIN; 8-L-Arginineoxytocin; VASOTOCIN ARG 8; CYIQNCPRG-NH2; AVT; (arg(sup8))oxytocin

物化性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₄₃H₆₇N₁₅O₁₂S₂
• 分子量: 1050.215
• 精确质量: 1049.453491
• PSA: 512.03000
• LogP: -6.27
• 折射率: 1.713
• 储存条件:

  库房通风低温干燥

• 稳定性:

  可燃; 燃烧产生有毒氮氧化物和硫氧化物烟雾

• 计算化学:

  1.疏水参数计算参考值（XlogP）:-5.1

  2.氢键供体数量:14

  3.氢键受体数量:16

  4.可旋转化学键数量:19

  5.互变异构体数量:1001

  6.拓扑分子极性表面积515

  7.重原子数量:72

  8.表面电荷:0

  9.复杂度:1990

  10.同位素原子数量:0

  11.确定原子立构中心数量:7

  12.不确定原子立构中心数量:2

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: [Arg8]-Vasotocin是加压素/催产素激素家族的脊椎动物神经垂体肽。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体
  研究领域 >> 神经疾病
  多肽产品

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RS7534500 CHEMICAL NAME : Oxytocin, 8-L-arginine- CAS REGISTRY NUMBER : 113-80-4 LAST UPDATED : 199706 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C43-H67-N15-O12-S2 MOLECULAR WEIGHT : 1050.37 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 625 ug/kg SEX/DURATION : male 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 37,935,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 80 ug/kg SEX/DURATION : female 19 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,65,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 80 ug/kg SEX/DURATION : female 1-21 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,65,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 120 ug/kg SEX/DURATION : male 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 19,103,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 80 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 133,1254,1970 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 24 ug/kg SEX/DURATION : male 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 19,103,1974