10302-78-0

• 常用中文名：2',3',5'-三乙酰基氮杂胞苷
• 常用英文名：2',3',5'-triacetyl-5-Azacytidine
• CAS号：10302-78-0
• 分子式：C₁₄H₁₈N₄O₈
• 分子量：370.315
• 相关类别： 信号通路 表观遗传学 DNA甲基转移酶
• 发布时间：2018-12-21 20:24:49
• 更新时间：2026-07-01 18:42:23
• 2′,3′,5′-三乙酰基-5-氮杂胞苷是一种口服活性的5-氮杂胞苷前体药物。5-氮胞苷是DNA甲基转移酶的抑制剂[1]。

名称

• 中文名: 2',3',5'-三乙酰基-5-氮杂胞苷
• 英文名: 2',3',5'-Triacetyl -azacytidine
• 中文别名: 三乙酰基-阿扎胞苷; 阿扎胞苷杂质07; 三乙酰阿扎胞苷; 氮胞苷杂质K; 三乙酰基-阿扎胞苷,10 MM DMSO 溶液; 阿扎胞苷三乙酸酯; 三乙酰-5-氮胞苷; 2',3',5'-三乙酰基-5-氮杂胞苷 10-0; (2R,3R,4R,5R)-2-(乙酰氧基甲基)-5-(4-氨基-2-氧代-1,3,5-三嗪-1(2H)-基)四氢呋喃-3,4-二基二乙酸酯; 阿扎胞苷杂质40
• 英文别名: Azacitidine Triacetate; 2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine; 2'',3'',5''-triacetyl-5-Azacytidine; 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl); O-triacetate; Azacitidine Impurity 48; Triacetyl azacitidine; 2',3',5'-Tri-O-Acetyl-Azacytidine; 4-Amino-1-(2,3,5-tri-o-acetyl-beta-d-ribofuranosyl)-1,3,5-triazin-2(1h)-one; 2',3',5'-triacetyl-5-Azacytosine; S-Triazin-2(1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-, triacetate (ester); (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate; 2'3'5'-triacetyl-5-Azacytosine; triethylenetetramine-N,N,N',N'',N'''; 5-Azacytidine 2’,3’5’-O-triacetate; 2',3',5'-triacetyl-5-azacytidine; 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-o-acetyl-.beta.-D-ribofuranosyl); 2,3,5-tri-O-acetyl-5-azacytidine; Intermediate of Azacitidine; 4-Amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 2'',3'',5''-Triacetyl -azacytidine; 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl); 4-amino-1-(2,3,5-tri-O-acetylpentofuranosyl)-1,3,5-triazin-2(1H)-one; 2′,3′,5′-Triacetyl-azacytidine; 1,3,5-Triazin-2(1H)-one,4-amino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl); 2'',3'',5''-triacetyl-5-Azacytidine, 10 mM in DMSO; 5-azacytidine triacetate; 2',3',5'-Tri-O-acetyl-5-azacytidine; Nsc291930

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 497.3±55.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈N₄O₈
• 分子量: 370.315
• 闪点: 254.6±31.5 °C
• 精确质量: 370.112457
• PSA: 161.93000
• LogP: -0.60
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.634
• 储存条件: 2-8°C，避光，保存于惰性气体中

生物活性

• 描述: 2′,3′,5′-三乙酰基-5-氮杂胞苷是一种口服活性的5-氮杂胞苷前体药物。5-氮胞苷是DNA甲基转移酶的抑制剂[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> DNA甲基转移酶
• 参考文献:

  [1]. Ziemba A, et, al. Development of an oral form of azacytidine: 2'3'5'triacetyl-5-azacytidine. Chemother Res Pract. 2011;2011:965826.

合成路线

52523-35-0 13035-61-5 ~66% 10302-78-0

文献：PHARMION LLC; RAJENDIRAN, Chinnapillai; NAGARAJAN, Periyandi; VENKATESWARLAU, Jasti Patent: WO2012/135405 A1, 2012 ; Location in patent: Page/Page column 64-67 ;

40554-98-1 52523-35-0 ~% 10302-78-0

文献：SICOR INC.; BIGATTI, Ettore; LUX, Giovanna; PAIOCCHI, Maurizio; GIOLITO, Andrea; TOSI, Simone Patent: WO2010/17374 A1, 2010 ; Location in patent: Page/Page column 17-18 ;

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