15991-13-6

• 常用中文名：Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
• 常用英文名：Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
• CAS号：15991-13-6
• 分子式：C₁₂H₁₀O₅
• 分子量：234.20500
• 相关类别： 研究领域 其他
• 发布时间：2016-11-06 15:53:54
• 更新时间：2024-01-23 12:41:35
• Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate 是一种天然香豆素衍生物,合成用于细菌酶检测的可切换荧光底物。

名称

• 英文名: methyl 2-(7-hydroxy-2-oxochromen-4-yl)acetate
• 英文别名: methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate; methyl (7-hydroxy-2-oxo-2H-chromen-4-yl)acetate; (7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid methyl ester; 7-hydroxy-4-methoxycarbonylmethyl-2H-chromen-2-one; methyl 2-(7-hydroxy-2-oxochromen-4-yl) acetate; (7'-hydroxycoumarin-4-yl)acetic acid methyl ester; 7-hydroxycoumarin-4-acetic acid methyl ester

物化性质

• 分子式: C₁₂H₁₀O₅
• 分子量: 234.20500
• 精确质量: 234.05300
• PSA: 76.74000
• LogP: 1.21410

生物活性

• 描述: Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate 是一种天然香豆素衍生物,合成用于细菌酶检测的可切换荧光底物。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 2-(7-羟基-2-氧代-2H-铬-4-基)乙酸甲酯(化合物2)具有最大的吸收(λabs~322nm)和发射(λem~387nm)波长[2]。
• 参考文献:

  [1]. Nascimento JSD, et al. Mapping the Biotransformation of Coumarins through Filamentous Fungi. Molecules. 2019 Sep 29;24(19).

  [2]. Lizzul-Jurse A, et al. Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry. Org Biomol Chem. 2016 Aug 10;14(32):7777-91.

  [3]. Giovannini G, et al. Coumarin-based, switchable fluorescent substrates for enzymatic bacterial detection. Talanta. 2018 Oct 1;188:448-453.

安全

• 海关编码: 2932209090

合成路线

67-56-1 6950-82-9 ~96% 15991-13-6

文献：Holmes, Christopher P.; Macher, Natalie; Grove, J. Russell; Jang, Larry; Irvine, Jennifer D. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3382 - 3385

1830-54-2 108-46-3 ~91% 15991-13-6

文献：Smitha; Reddy, Ch. Sanjeeva Synthetic Communications, 2004 , vol. 34, # 21 p. 3997 - 4003

1830-54-2 108-46-3 ~60% 15991-13-6 780821-74-1

文献：Dubovik; Garazd; Khilya Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 3 p. 277 - 281

542-05-2 ~% 15991-13-6

文献：Brubaker; DeRuiter; Whitmer Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1094 - 1099

108-46-3 ~% 15991-13-6

文献：Baker et al. Journal of the Chemical Society, 1950 , p. 170,172

77-92-9 ~% 15991-13-6

文献：Baker et al. Journal of the Chemical Society, 1950 , p. 170,172

608529-85-7 ~% 15991-13-6

文献：Holmes, Christopher P.; Macher, Natalie; Grove, J. Russell; Jang, Larry; Irvine, Jennifer D. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3382 - 3385

上下游产品

上游产品  7
67-56-1 6950-82-9 1830-54-2 108-46-3
542-05-2 77-92-9 608529-85-7
下游产品  6
62935-72-2 6950-82-9 127615-74-1 127615-75-2
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海关

海关编码	2932209090
中文概述	2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%