145195-63-7

• 常用中文名：(2Z)-2-氰基-3-(3,4-二羟基-5-硝基苯基)-N,N-二乙基-2-丙烯酰胺
• 常用英文名：cis-entacapone
• CAS号：145195-63-7
• 分子式：C₁₄H₁₅N₃O₅
• 分子量：305.28600
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-12-22 05:03:04
• 更新时间：2026-08-31 11:59:26
• cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone. It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.

名称

• 中文名: (2Z)-2-氰基-3-(3,4-二羟基-5-硝基苯基)-N,N-二乙基-2-丙烯酰胺
• 英文名: (Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
• 中文别名: 顺式-安托卡朋; 恩他卡朋杂质A 标准品; 恩他卡朋相关物质A; 恩他卡朋相关物质A 标准品; 顺式-恩他卡朋; 恩他卡朋欧洲药典杂质A; 恩他卡朋杂质A; 恩他卡朋 杂质 A(恩他卡朋 相关化合物 A,顺式恩他卡朋); 顺式恩他卡朋; 恩他卡朋相关化合物A; 恩他卡朋A; 恩他卡朋杂质ZCNA; (Z)-恩他卡朋; 恩他卡朋杂质1(恩他卡朋杂质A); 恩他卡朋杂质A(顺式恩他卡朋)
• 英文别名: Entacapone Impurity 17(Entacapone Impurity A); Entacapone impurity A; (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nit; Entacapone impurity A -I; Entacapen impurity A; Entacapone-d10 (cis); UNII-4X96VV9HUQ; (Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide; Entacapone Related Compound A ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide); (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide; 4-dihydroxy-5-nitrophenyl) acrylamide; Z Entacapone/ impurity A/RC A; Entacapone Impurity A (Entacapone Related Compound A, cis-Entacapone); Entacapone impurity A CRS; (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; (Z)-Entacapone; Entacapone Related Compound A; Entacapone Z-isomer / Entacapone Related Compound-A / Entacapone Impurity-A; CIS-ENTACAPONE; Entacapone Impurity 1（Entacapone Impurity A）; 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2Z); Entacapone Related Compound A (25 mg) ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide); cis-Entacapone; Entacapone Impurity A (cis-Entacapone)

物化性质

• 熔点: 142-144°C
• 分子式: C₁₄H₁₅N₃O₅
• 分子量: 305.28600
• 精确质量: 305.10100
• PSA: 130.38000
• LogP: 2.30458
• 储存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

26391-06-0 116313-85-0 ~0% 130929-57-6 145195-63-7

文献：WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; KHAN, Rashid, Abdul, Rehman; YADAV, Ram, Prasad; SHAIKH, Zakir, Gafoor Patent: WO2005/66117 A1, 2005 ; Location in patent: Page/Page column 11 ;

146698-91-1 ~% 130929-57-6 145195-63-7

文献：WO2007/94007 A1, ; Page/Page column 15 ;

686349-59-7 ~% 145195-63-7

文献：WO2007/94007 A1, ; Page/Page column 16 ;

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