1474-53-9

• 常用中文名：17-Beta-雌二醇 3-甲醚
• 常用英文名：17-β-ESTRADIOL 3-METHYL ETHER
• CAS号：1474-53-9
• 分子式：C₁₉H₂₆O₃
• 分子量：302.40800
• 发布时间：2018-12-24 17:23:34
• 更新时间：2026-08-23 18:47:52

名称

• 中文名: 17-Beta-雌二醇 3-甲醚
• 英文名: 17-β-ESTRADIOL 3-METHYL ETHER
• 中文别名: 雌三醇杂质C 标准品; 雌三醇 3-甲醚; 雌三醇杂质3(雌三醇杂质C); 结合雌激素杂质C; 17-β-雌二醇-3-甲醚; 雌三醇杂质C
• 英文别名: ESTRIOL 3-METHYL ETHER; 3-Methoxyestriol; 1,3,5-ESTRATRIENE-3,16ALPHA,17BETA-TRIOL 3-METHYL ETHER; BETA-ESTRADIOL 3-METHYL ETHER; 1,3,5-ESTRATRIEN-3,17-BETA-DIOL 3-METHYL ETHER; BETA-ETHYLESTRADIOL 3-METHYL ETHER; 1,3,5-estratriene-3,16α,17β-triol 3-methyl ether; ESTRIOL METHYL ETHER; 5-triene-16,17-diol,3-methoxy-,(16-alpha,17-beta)-estra-3; 5-triene-16-alpha,17-beta-diol,3-methoxy-estra-3; 3,17B-ESTRADIOL 3-METHYL ETHER; 3-Methoxyestra-1,2,4-triene-16α,17β-diol; BENZOYLOXY 17BETA-ESTROL; (8R,9S,13S,14S,16R,17R)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol; Estriol Impurity C; 1,3,5-ESTRATRIENE-3,17BETA-DIOL 3-METHYL ETHER; (8R,9S,13S,14S,17S)-3-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-OL; Estra-1,3,5-triene-16,17-diol, 3-methoxy-, (16α,17β); 3,17BETA-DIHYDROXY-1,3,5-ESTRATRIENE 3-METHYL ETHER; 3-Methoxy-1,3,5-estratriene-16α,17β-diol; 1, 3, 5-ESTRATRIEN-3, 16α, 17β-TRIOL 3-METHYL ETHER; 3-Methoxyestra-1,3,5-triene-16a; Estriol Impurity 3 (Estriol Impurity C); 3-Methoxyestra-1,3,5-triene-16alpha,17beta-diol (Estriol 3-Methyl Ether); 3-METHYLESTRIOL; oestriol 3-methyl ether; 3,16α,17β-Trihydroxy-1,3,5-estratriene 3-methyl ether; BETA-ESTRIOL 3-METHYL ETHER; Conjugated Estrogens Impurity C; 1,3,5-ESTRATRIEN-3,16-ALPHA, 17-BETA-TRIOL 3-METHYL ETHER; 3-methoxyestriol; 1,3,5-Estratriene-3,16α,17β-triol 3-methyl ether, 3,16α,17β-Trihydroxy-1,3,5-estratriene 3-methyl ether; 3,16ALPHA,17BETA-TRIHYDROXY-1,3,5-ESTRATRIENE 3-METHYL ETHER; 3-methoxy-14-acetoxydibenz<a,j>anthracene

物化性质

• 密度: 1.185g/cm3
• 沸点: 450.8ºC at 760mmHg
• 分子式: C₁₉H₂₆O₃
• 分子量: 302.40800
• 闪点: 226.4ºC
• 精确质量: 302.18800
• PSA: 49.69000
• LogP: 2.88300
• 蒸汽压: 6.48E-09mmHg at 25°C
• 折射率: 1.588

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KG7540000 CHEMICAL NAME : Estra-1,3,5(10)-triene-16-alpha,17-beta-diol, 3-methoxy- CAS REGISTRY NUMBER : 1474-53-9 LAST UPDATED : 199304 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C19-H26-O3 MOLECULAR WEIGHT : 302.45 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 5600 ug/kg SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 15,16,1977

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 40
• 安全声明 (欧洲): 36/37

合成路线

50-27-1 77-78-1 ~% 1474-53-9

文献：Freudenhammer, Christoph; Grotemeyer, Juergen European Journal of Mass Spectrometry, 2010 , vol. 16, # 4 p. 489 - 501

24721-15-1 ~% 1474-53-9 3434-79-5

文献：Sheehan et al. Journal of the American Chemical Society, 1957 , vol. 79, p. 147,148

186581-53-3 50-27-1 ~% 1474-53-9

文献：Schindler Helvetica Chimica Acta, 1959 , vol. 42, p. 1955,1958

50-27-1 75-59-2 ~% 1474-53-9

文献：MacGee; Allen Steroids, 1970 , vol. 16, # 1 p. 79 - 84

64-17-5 24721-15-1 64-19-7 ~% 1474-53-9

文献：Huffman Journal of Biological Chemistry, 1947 , vol. 169, p. 167,169

24721-15-1 67-63-0 ~% 1474-53-9

文献：Butenandt; Schaeffler Zeitschrift fuer Naturforschung, 1946 , vol. 1, p. 82,85

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