83207-58-3

• 常用中文名：黄芪甲苷A(黄芪甲苷 IV)
• 常用英文名：Astragaloside A
• CAS号：83207-58-3
• 分子式：C₄₁H₆₈O₁₄
• 分子量：784.970
• 相关类别： 生物化工 天然产物
• 发布时间：2018-03-23 08:00:00
• 更新时间：2024-01-03 00:40:12
• 黄芪甲苷Astragaloside A 是黄芪在中医的主要活性成分；已广泛用于治疗缺血性疾病。

名称

• 中文名: 黄芪甲苷
• 英文名: astragaloside IV
• 中文别名: 黄芪皂苷IV
• 英文别名: Astragalus Polysaccharides; (3β,6α,9β,16β,20R,24S)-16,25-Dihydroxy-3-(β-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside; ASTRAGALOSIDE; ASTRAGALOSIDE IV(RG); Astrasieversianin XIV; Astragaloside IV; Astragaloside A; β-D-Glucopyranoside, (3β,6α,9β,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl; cyclosiversioside F; cyclosieversioside F

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 895.7±65.0 °C at 760 mmHg
• 熔点: 284-286ºC
• 分子式: C₄₁H₆₈O₁₄
• 分子量: 784.970
• 闪点: 495.5±34.3 °C
• 精确质量: 784.460938
• PSA: 228.22000
• LogP: 1.96
• 外观性状: 白色粉末
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.621
• 储存条件: 2~8℃

生物活性

• 描述: 黄芪甲苷Astragaloside A 是黄芪在中医的主要活性成分；已广泛用于治疗缺血性疾病。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 萜类化合物和糖苷
  研究领域 >> 癌症
• 参考文献:

  [1]. Wang SG, et al. Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway. Molecules. 2013 Oct 16;18(10):12809-19.

  [2]. Lu M, et al. Astragaloside IV protects against cardiac hypertrophy via inhibiting the Ca2+/CaN signaling pathway. Planta Med. 2014 Jan;80(1):63-9.

  [3]. Wang Q, et al. Astragalosides IV inhibits high glucose-induced cell apoptosis through HGF activation in cultured human tubular epithelial cells. Ren Fail. 2014 Apr;36(3):400-6.

  [4]. Zhang A, et al. Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO. J Cancer Res Clin Oncol. 2014 Nov;140(11):1883-90.

  [5]. Xu W, et al. Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro. J Pharmacol Exp Ther. 2014 Sep;350(3):552-62.

安全

• 危害码 (欧洲): Xi
• 海关编码: 2932999099

合成路线

84687-46-7 ~% 83207-58-3 86764-12-7

文献：Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 716 - 722

84687-45-6 ~% 83207-58-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 709 - 715

86764-11-6 ~% 83207-58-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

84676-88-0 ~% 83207-58-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

84687-47-8 ~% 83207-58-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

84676-89-1 ~% 83207-58-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

84680-75-1 ~% 83207-58-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

223924-10-5 ~% 83207-58-3

文献：Chemistry of Natural Compounds, , vol. 40, # 1 p. 40 - 44

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海关

海关编码	2932999099
中文概述	2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%