501332-69-0

501332-69-0结构式

常用中文名：Idetrexed
常用英文名：Idetrexed
CAS号：501332-69-0
分子式：C₃₂H₃₃N₅O₁₀
分子量：647.63
相关类别：信号通路细胞凋亡胸苷酸合成酶
发布时间：2017-12-16 04:30:32
更新时间：2026-07-09 20:46:31
iDetrex是一种胸苷酸合成酶抑制剂,特异性转运到α-叶酸受体(α-FR)-过表达的肿瘤中。BGC 945抑制胸苷酸合成酶,Ki为1.2 nmol/L[1][2]。

英文名	L-γ-Glutamyl-N-(4-{[(6S)-2-(hydroxymethyl)-4-oxo-4,6,7,8-tetrahyd ro-1H-cyclopenta[g]quinazolin-6-yl](2-propyn-1-yl)amino}benzoyl)- D-glutamic acid
英文别名	(2R)-2-[[(4S)-4-cboxy-4-[[4-[[(6S)-2-(hydroxymethyl)-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl]-prop-2-ynylamino]benzoyl]amino]butanoyl]amino]pentanedioic acid ONX-0801 D-Glutamic acid, N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl Idetrexed/B945/ONX-0801 D-GlutaMic acid, N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxyMethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutaMyl-yl]amino]benzoyl]-L-γ-glutaMyl N-[4-[2-Propyn-1-Yl-[(6s)-4,6,7,8-Tetrahydro-2- (Hydroxymethyl)-4-Oxo-3h- Cyclopenta[G]Quinazolin-6-Yl]Amino]Benzoyl]-L- Gamma-Glutamyl-D-Glutamic Acid

描述	iDetrex是一种胸苷酸合成酶抑制剂,特异性转运到α-叶酸受体(α-FR)-过表达的肿瘤中。BGC 945抑制胸苷酸合成酶,Ki为1.2 nmol/L[1][2]。
相关类别	信号通路 >> 细胞凋亡 >> 胸苷酸合成酶研究领域 >> 其他
参考文献	[1]. Gibbs DD, Theti DS, Wood N, Green M, Raynaud F, Valenti M, Forster MD, Mitchell F, Bavetsias V, Henderson E, Jackman AL. BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors. Cancer Res. 2005 Dec 15;65(24):11721-8. [2]. Tochowicz A, Dalziel S, Eidam O, O'Connell JD 3rd, Griner S, Finer-Moore JS, Stroud RM. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56(13):5446-55.