14759-06-9

• 常用中文名：磺达嗪
• 常用英文名：Thioridazine 2-Sulfone
• CAS号：14759-06-9
• 分子式：C₂₁H₂₆N₂O₂S₂
• 分子量：402.57300
• 发布时间：2018-05-25 08:00:00
• 更新时间：2026-07-03 16:20:21

名称

• 中文名: 磺达嗪
• 英文名: Thioridazine 2-Sulfone
• 中文别名: 10-(2-(1-甲基哌啶-2-基)乙基)-2-(甲基磺酰基)-10H-吩噻嗪 (硫立达嗪杂质); 盐酸硫利达嗪杂质E; 硫利达嗪杂质E
• 英文别名: sulforidazine; 10-[2-[(2RS)-1-Methylpiperidin-2-yl]ethyl]-2-(methylsulfonyl)-10H-phenothiazine; 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfonyl); Thioridazine Impurity E; Thioridazine Impurity 5 (Thioridazine Impurity E); 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine; 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylsulfonyl)-10H-phenothiazine (Thioridazine Impurity); 10-[2-[(2RS)-1-methylpiperidin-2-yl]ethyl]-2-(methylsulfonyl)-10H-phenothiazine (sulforidazine)

物化性质

• 密度: 1.221g/cm3
• 沸点: 589.1ºC at 760mmHg
• 分子式: C₂₁H₂₆N₂O₂S₂
• 分子量: 402.57300
• 闪点: 310.1ºC
• 精确质量: 402.14400
• PSA: 74.30000
• LogP: 5.65090
• 蒸汽压: 7.45E-14mmHg at 25°C
• 折射率: 1.605

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SP1925000 CHEMICAL NAME : Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-2-methylsulfonyl-, CAS REGISTRY NUMBER : 14759-06-9 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C21-H26-N2-O2-S2 MOLECULAR WEIGHT : 402.61 WISWESSER LINE NOTATION : T C666 BN ISJ ESW1 B2- BT6NTJ A1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 520 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 138 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1596,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 29 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972

安全

• 海关编码: 2934300000

合成路线

5588-33-0 ~52% 14759-06-9

文献：Morrow, Ryan J.; Millership, Jeff S.; Collier, Paul S. Helvetica Chimica Acta, 2005 , vol. 88, # 5 p. 962 - 967

50-52-2 ~% 14759-06-9

文献：Helvetica Chimica Acta, , vol. 88, # 5 p. 962 - 967

海关

海关编码	2934300000
中文概述	2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%