251111-30-5

• 常用中文名：Beloranib
• 常用英文名：Beloranib
• CAS号：251111-30-5
• 分子式：C₂₉H₄₁NO₆
• 分子量：499.63900
• 发布时间：2016-12-23 13:05:25
• 更新时间：2024-01-02 13:36:36
• Beloranib是一种抗血管生成的富马西林衍生物。Beloranib减少食物摄入量、体重、脂肪质量和脂肪细胞的大小。

名称

• 英文名: [(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]prop-2-enoate
• 英文别名: [(3R,6R,7S,8S)-7-methoxy-8-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-2-oxaspiro[2.5]octan-6-yl] (E)-3-[4-(2-dimethylaminoethyloxy)phenyl]prop-2-enoate; (3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro(2.5)octan-6-yl (2E)-3-(4-(2-(dimethylamino)ethoxy)phenyl)prop-2-enoate; Beloranib; UNII-FI471K8BU6; O-(4-(2-Dimethylaminoethoxy)-trans-cinnamoyl)fumagillol; Beloranib [INN]; ZGN-433

物化性质

• 分子式: C₂₉H₄₁NO₆
• 分子量: 499.63900
• 精确质量: 499.29300
• PSA: 73.06000
• LogP: 4.25980
• 储存条件: -20°C

生物活性

• 描述: Beloranib是一种抗血管生成的富马西林衍生物。Beloranib减少食物摄入量、体重、脂肪质量和脂肪细胞的大小。
• 参考文献:

  [1]. Elfers CT, Roth CL. Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity. Endocrinology. 2017;158(1):41-55.

  [2]. Kim YM, An JJ, Jin YJ, et al. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J Mol Endocrinol. 2007;38(4):455-465.

  [3]. Lee HS, Choi WK, Son HJ, et al. Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs. Arch Pharm Res. 2004;27(2):265-272.

  [4]. Kim EJ, Shin WH. General pharmacology of CKD-732, a new anticancer agent: effects on central nervous, cardiovascular, and respiratory system. Biol Pharm Bull. 2005;28(2):217-223.