591778-68-6

• 常用中文名：CP-640186
• 常用英文名：CP-640186
• CAS号：591778-68-6
• 分子式：C₃₀H₃₅N₃O₃
• 分子量：485.617
• 相关类别： 信号通路 代谢酶/蛋白酶 乙酰辅酶A羧化酶
• 发布时间：2016-08-17 03:57:24
• 更新时间：2026-07-02 18:52:27
• CP-640186是乙酰辅酶A羧化酶(ACCase)抑制剂,对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM,比CP-610431有更好的代谢稳定性。

名称

• 中文名: CP-640186
• 英文名: [(3R)-1-[1-(anthracene-9-carbonyl)piperidin-4-yl]piperidin-3-yl]-morpholin-4-ylmethanone
• 中文别名: (R)-蒽-9-基(3-(吗啉-4-羰基)-1,4'-双哌啶-1'-基)甲酮盐酸盐; (R)-蒽-9-基(3-(吗啉-4-羰基)-[1,4'-联哌啶]-1'-基)甲酮
• 英文别名: 640186 (R)-ANTHRACEN-9-YL(3-(MORPHOLINE-4-carbonyl)-1,4'-BIPIPERIDIN-1'-YL)METHANONE.HCL; 9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone; H460,HG2,Acetyl-CoA Cboxylase,-640186,human fibroblasts,Inhibitor,inhibit,muscle fatty acid oxidation,ACC, Acetyl Coenzyme A Cboxylase,640186,C2C12,muscle strips; 640186, 10 mM in DMSO; (R)-Anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)methanone; (Anthracen-9-yl)[(3R)-3-[(morpholin-4-yl)carbonyl][1,4']bipiperidinyl-1'-yl]methanone; Methanone, [(3R)-1'-(9-anthracenylcbonyl)[1,4'-bipiperidin]-3-yl]-4-morpholinyl; 1w2x; UNII-04L1E4J3ZT; (R)-ANTHRACEN-9-YL(3-(MORPHOLINE-4-carbonyl)-1,4'-BIPIPERIDIN-1'-YL)METHANONE.HCL; CP 640186; (R)-anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)metha none 640186; 640186 ，S6753; 640186;-640186; RCP

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 721.1±60.0 °C at 760 mmHg
• 分子式: C₃₀H₃₅N₃O₃
• 分子量: 485.617
• 闪点: 389.9±32.9 °C
• 精确质量: 485.267853
• PSA: 53.09000
• LogP: 3.49
• 外观性状: 浅黄色固体
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.654
• 储存条件: -20℃

生物活性

• 描述: CP-640186是乙酰辅酶A羧化酶(ACCase)抑制剂,对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM,比CP-610431有更好的代谢稳定性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 乙酰辅酶A羧化酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111.

  [2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.