943133-81-1

943133-81-1结构式

常用中文名：GAP-134 Hydrochloride
常用英文名：GAP-134 (Hydrochloride)
CAS号：943133-81-1
分子式：C₁₄H₁₈ClN₃O₄
分子量：327.76300
相关类别：多肽产品
发布时间：2017-12-16 22:39:49
更新时间：2026-07-01 17:39:34
Danegaptide Hydrochloride (GAP-134 Hydrochloride) 是一种选择性的缝隙连接 (gap junction) 调节剂。

中文名	Danegaptide Hydrochloride
英文名	(2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid,hydrochloride
中文别名	(4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸盐酸盐,10 MM DMSO 溶液 GAP-134盐酸盐 Danegaptide Hydrochloride试剂 (4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸盐酸盐 (2S,4R)-4-苯甲酰胺-1-甘氨酰吡咯烷-2-甲酸盐酸盐 2H5]-丹那肽盐酸盐
英文别名	GAP-134 hydrochloride (Danegaptide Hydrochloride 2H5]-Danegaptide hydrochloride salt GAP 134 Hydrochloride Danegaptide Hydrochloride, 10 mM in DMSO ZP1609 Hydrochloride GAP-134 HYDROCHLORIDE (4R)-Glycyl-4-(benzoylamino)-L-proline hydrochloride (1:1) Danegaptide (GAP-134) hydrochloride (2S,4R)-4-Benzamido-1-glycylpyrrolidine-2-cboxylic acid hydrochloride CS-1101 ZP-1609,ZP 1609,GAP 134,Danegaptide,antirhythmic,inhibit,diptide,Danegaptide Hydrochloride,Gap Junction Protein,ZP1609,GAP134,GAP-134,Cdioprotective,orally,Inhibitor ZP-1609 Hydrochloride GAP-134 Hydrochloride,Danegaptide Hydrochloride,ZP 1609 Hydrochloride Danegaptide hydrochloride salt (2S;4R)-1-(2-AMINOACETYL)-4-BENZAMIDOPYRROLIDINE-2-CBOXYLIC ACID;HYDROCHLORIDE GAP134 Hydrochloride DANEGAPTIDE HYDROCHLORIDE;ZP1609 HYDROCHLORIDE;GAP134 HYDROCHLORIDE;GAP 134 HYDROCHLORIDE;ZP-1609 HYDROCHLORIDE;ZP 1609 HYDROCHLORIDE Danegaptide Hydrochloride ZP 1609 Hydrochloride 4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-cboxylic acid

描述	Danegaptide Hydrochloride (GAP-134 Hydrochloride) 是一种选择性的缝隙连接 (gap junction) 调节剂。
相关类别	信号通路 >> 细胞骨架 >> 间隙连接蛋白多肽产品研究领域 >> 心血管疾病
靶点	Gap junction.
参考文献	[1]. De Vuyst E, Boengler K, Antoons G, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. [2]. Laurent G, Leong-Poi H, Mangat I, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8. [3]. Hennan JK, Swillo RE, Morgan GA, et al. GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14. [4]. Rossman EI, Liu K, Morgan GA, et al. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33. [5]. Eugene L. Piatnitski Cheklera, John A. Buterab, Li Dib, Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters. 2009,19(16): 4551-4554