943133-81-1

943133-81-1 structure

Name: GAP-134 (Hydrochloride)
Chemical Name: (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid,hydrochloride
CAS Number: 943133-81-1
Molecular Formula: C₁₄H₁₈ClN₃O₄
Molecular Weight: 327.76300
Catalog: Peptides
Create Date: 2017-12-16 22:39:49
Modify Date: 2025-09-23 06:19:10
Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.

Name	(2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid,hydrochloride
Synonyms	GAP134 Hydrochloride ZP1609 Hydrochloride CS-1101 GAP-134 (Hydrochloride)

Description	Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Gap Junction Protein Peptides Research Areas >> Cardiovascular Disease
Target	Gap junction.
References	[1]. De Vuyst E, Boengler K, Antoons G, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. [2]. Laurent G, Leong-Poi H, Mangat I, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8. [3]. Hennan JK, Swillo RE, Morgan GA, et al. GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14. [4]. Rossman EI, Liu K, Morgan GA, et al. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33. [5]. Eugene L. Piatnitski Cheklera, John A. Buterab, Li Dib, Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters. 2009,19(16): 4551-4554