2955-27-3

• 常用中文名：熊果酸
• 常用英文名：Ursocholic acid
• CAS号：2955-27-3
• 分子式：C₂₄H₄₀O₅
• 分子量：408.57100
• 相关类别： 天然产物 其他
• 发布时间：2017-10-25 22:54:22
• 更新时间：2026-07-12 11:54:01
• Ursocholic acid,一种存在于哺乳动物胆汁中的胆酸,是7α-羟化类固醇脱氢酶 (7α-hydroxysteroid dehydrogenase) 和肝细胞核因子1α (hepatocyte nuclear factor 1α) 的抑制剂。

名称

• 中文名: 熊果酸
• 英文名: Ursocholic Acid
• 中文别名: 3α,7β,12α-三羟基-5β-胆酸-24-油酸(熊去氧胆酸); 4-[(5S,7S,8S,10S,13R,17R)-3,7,12-三羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊二烯并[A]菲-17-基]戊酸; 熊去氧胆酸杂质4(熊去氧胆酸杂质D); 熊去氧胆酸杂质D; 鹅去氧胆酸杂质D; 熊胆酸(鹅去氧胆酸杂质D,熊去氧胆酸杂质D); (R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S,17R)-3,7,12-三羟基-10,13-二甲基十六氢-1H-环戊[A]菲-17-基)戊酸; 3A,7B,12A-三羟基-5Β-胆甾烷-24-酸; 熊果胆酸; 熊果酸(鹅去氧胆酸杂质D,熊去氧胆酸杂质D); 熊胆酸(URSOCHOLIC ACID,熊果胆酸); 熊去氧胆酸杂质5; 3Α,7Β,12Α-三羟基-5Β-胆酸-24-油酸(熊去氧胆酸); 熊果胆酸,10 MM DMSO 溶液; 3Α,7Β,12Α-三羟基-5Β-胆酸-24-油酸
• 英文别名: Ursocholic acid, 10 mM in DMSO; (R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; 3|A,7|A,12|A-Trihydroxy-5|A-cholanoic Acid; Ursocholate; 5β-CHOLANIC ACID-3α, 7β, 12α-TRIOL; 3-Epicholic acid; Ursocholic acid,inhibit,Inhibitor,Endogenous Metabolite; 3α,7β,12α-trihydroxy-5β-cholan-24-oicacid(ursocholicacid); Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7β,12α); Ursodeoxycholic acid Imp. D : 3α,7β,12α-trihydroxy-5β-cholan-24-oic acid (Ursocholic acid); 3|A-Cholic Acid; 7-icholic Acid; Cholan-24-oic acid,3,7,12-trihydroxy-, (3a,5b,7b,12a); Ursodiol Impurity D; (4R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; 4-[(5S,7S,8S,10S,13R,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid //BP; Chenodeoxycholic Acid Impurity 4; 4-[(5S,7S,8S,10S,13R,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; Urosodeoxycholic Acid Impurity D; Ursodeoxycholic Acid Impurity 4（Ursodeoxycholic Acid Impurity D）; Ursodeoxycholic Acid Impurity D,3α,7β,12α-trihydroxy -5β-cholan-24-oic acid(ursocholic acid); 7β-Hydroxyisocholic Acid; 3α,7β,12α-trihydroxy-5β-cholan-24-oic Acid; Ursodeoxycholic Acid Impurity D; Ursocholic Acid (Chenodeoxycholic Acid Impurity D, Ursodeoxycholic Acid Impurity D); Chenodeoxycholic Acid Impurity D; 3a,7B,12a-trihydroxy-5B-cholan-24-oic acid (Ursocholic acid); Ursodeoxycholic Acid Impurity D/Ursocholic Acid/(R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; Ursodeoxycholic Acid Impurity 5

物化性质

• 密度: 1.184g/cm3
• 沸点: 583.9ºC at 760mmHg
• 分子式: C₂₄H₄₀O₅
• 分子量: 408.57100
• 闪点: 321ºC
• 精确质量: 408.28800
• PSA: 97.99000
• LogP: 3.44870
• 储存条件: 2-8℃

生物活性

• 描述: Ursocholic acid,一种存在于哺乳动物胆汁中的胆酸,是7α-羟化类固醇脱氢酶 (7α-hydroxysteroid dehydrogenase) 和肝细胞核因子1α (hepatocyte nuclear factor 1α) 的抑制剂。
• 相关类别:
  天然产物 >> 其他
  研究领域 >> 代谢疾病
• 靶点:

  Human Endogenous Metabolite

• 参考文献:

  [1]. MacDonald IA, et al. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms. Appl Environ Microbiol. 1982 Nov;44(5):1187-95.

  [2]. Lee HI, et al. Ursodeoxycholic acid, an inhibitor of hepatocyte nuclear factor 1α, did not increase the systemic exposure of pitavastatin. Int J Clin Pharmacol Ther. 2014 Nov;52(11):981-5.