100361-18-0

• 常用中文名：环丙基萘啶羧酸
• 常用英文名：1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• CAS号：100361-18-0
• 分子式：C₁₂H₈ClFN₂O₃
• 分子量：282.655
• 相关类别： 化学试剂 有机试剂 芳烃
• 发布时间：2018-05-23 08:00:00
• 更新时间：2026-07-07 09:49:08

名称

• 中文名: 环丙基萘啶羧酸
• 英文名: 7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid
• 中文别名: 1-环丙基-4-氧代-6-氟-7-氯-1,4-二氢-1,8-萘啶-3-甲酸; 环丙基萘啶羧酸:吉米沙星母核-1; 吉米沙星母核; 环丙萘啶羧酸; 7-氯-1-环丙基-6-氟-1,4-二氢-4-氧-1,8-萘啶-3-羧酸; 环丙基奈啶羧酸; 1-环丙基-6-氟-7-氯-4-氧-1,4-二氢-1,8-萘啶-3-羧酸
• 英文别名: Nalidixic acid cyclopropyl; 7-Chloro-1-cyclopropyl-1,4-dihydro-3-oxo-1,8-naphthyridine-3-cboxylic aci; 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYIDINE CBOXYLIC ACID; 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1; 1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1; 7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-CboxylicAci; 7-Chloro-1-cyclopropyl-6-fluor; T66 BV EN GNJ CVQ HG IF E- AL3TJ; 1-CYCLOPROPYL-6-FLUORO-7-CHLORIDE-4-OXO-1,4-DIHYDRO-1,8-NAPTHYRIDINE-3-CBOXYLIE ACID; 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 3-Cboxy-7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine; 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-cboxylic acid; 7-Chloro-1-cycloprop; 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic Acid; 7-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Qxoquinoline-3-CboxylicAcid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyl ridine cbox.acid; 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylic acid; 1,8-Naphthyridine-3-cboxylicacid, 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo; 8-naphthyridine-3-cboxylic acid; 1-Cyclopropyl-6-Fluoro-7-Chloro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Cboxylie acid; 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYLPYRIDINECBOXYLIC ACID; 1-CYCLOPROPYL-6-FLUORO-7-CHLORIDE-4-OXO-1,4-DIHYDRO-1,8-NAPTHYRIDINE-3-CBOXYLIC ACID; 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-cboxylic acid; 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-napthyridine-3-cboxylic acid; 7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Cboxylic; 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-cboxylic acid; 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-Ox; (S)-2-amino-3-(2,4-diMethylphenyl)propanoic acid; 7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridin-3-Cboxylic Acid; Gemifloxacin 7-Chloro Impurity; 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-cboxylicacid

物化性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 485.9±45.0 °C at 760 mmHg
• 熔点: 224 °C
• 分子式: C₁₂H₈ClFN₂O₃
• 分子量: 282.655
• 闪点: 247.7±28.7 °C
• 精确质量: 282.020752
• PSA: 72.19000
• LogP: 1.39
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.692
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

96568-07-9 ~76% 100361-18-0

文献：Karoli, Tomislav; Mamidyala, Sreeman K.; Zuegg, Johannes; Fry, Scott R.; Tee, Ernest H.L.; Bradford, Tanya A.; Madala, Praveen K.; Huang, Johnny X.; Ramu, Soumya; Butler, Mark S.; Cooper, Matthew A. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2428 - 2433

99735-42-9 ~% 100361-18-0

文献：US5281612 A1, ;

99735-36-1 ~% 99735-37-2 100361-18-0

文献：US4571396 A1, ;

96568-04-6 ~% 100361-18-0

文献：Journal of Medicinal Chemistry, , vol. 45, # 25 p. 5564 - 5575

96568-06-8 ~% 100361-18-0

文献：Journal of Medicinal Chemistry, , vol. 45, # 25 p. 5564 - 5575

96568-04-6 122-51-0 765-30-0 ~% 100361-18-0

文献：Journal of Medicinal Chemistry, , vol. 36, # 7 p. 871 - 882

上下游产品

上游产品  5
96568-07-9 99735-42-9 96568-04-6 122-51-0
765-30-0
下游产品  3
96568-07-9 113533-65-6 122536-91-8

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%